Title : FK506-binding protein mutational analysis: defining the active-site residue contributions to catalysis and the stability of ligand complexes.

Pub. Date : 1996 Feb

PMID : 9005438






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The 12 kDa FK506-binding protein FKBP12 is a cis-trans peptidyl-prolyl isomerase that binds the macrolides FK506 and rapamycin. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
2 For each mutant FKBP12, we measured the affinity for FK506 and rapamycin and the catalytic efficiency in the cis-frans peptidyl-prolyl isomerase reaction. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens
3 The mutation of Trp59 or Phe99 generates an FKBP12 with a significantly lower affinity for FK506 than wild-type protein. Tacrolimus FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens