Pub. Date : 2015 Apr
PMID : 25662675
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The variant organic cation transporter 2 (OCT2)-T201M contribute to changes in insulin resistance in patients with type 2 diabetes treated with metformin. | Metformin | solute carrier family 22 member 2 | Homo sapiens |
| 2 | The variant organic cation transporter 2 (OCT2)-T201M contribute to changes in insulin resistance in patients with type 2 diabetes treated with metformin. | Metformin | solute carrier family 22 member 2 | Homo sapiens |
| 3 | Organic cation transporter 2 (OCT2) is responsible for 80% metformin clearance. | Metformin | solute carrier family 22 member 2 | Homo sapiens |
| 4 | Organic cation transporter 2 (OCT2) is responsible for 80% metformin clearance. | Metformin | solute carrier family 22 member 2 | Homo sapiens |
| 5 | In this study, we examined the role of OCT2-T201M (602 C>T) variant in insulin resistance in patients with type 2 diabetes (T2D) who were treated with metformin. | Metformin | solute carrier family 22 member 2 | Homo sapiens |
| 6 | CONCLUSIONS: Our findings suggest that the loss-of-function variant OCT2-T201M (rs145450955) contribute to changes in insulin resistance and beta cell activity in patients with T2D treated with metformin. | Metformin | solute carrier family 22 member 2 | Homo sapiens |