Title : Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects.

Pub. Date : 2021 Apr

PMID : 32989831






1 Functional Relationships(s)
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1 In vitro, tucatinib inhibited OCT2-, MATE1-, and MATE2-K-mediated transport of metformin, with IC50 values of 14.7, 0.340, and 0.135 microM, respectively. Metformin solute carrier family 22 member 2 Homo sapiens