Title : Assessment of vandetanib as an inhibitor of various human renal transporters: inhibition of multidrug and toxin extrusion as a possible mechanism leading to decreased cisplatin and creatinine clearance.

Pub. Date : 2013 Dec

PMID : 24026623






1 Functional Relationships(s)
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1 Although no inhibition of OAT1 and OAT3 was observed, inhibition of OCT2-mediated uptake of 1-methyl-4-phenylpyridinium (MPP(+)) and metformin was evident (IC(50) of 73.4 +- 14.8 and 8.8 +- 1.9 microM, respectively). Metformin solute carrier family 22 member 2 Homo sapiens