| 1 |
35430566 | SLFN12 Over-expression Sensitizes Triple Negative Breast Cancer Cells to Chemotherapy Drugs and Radiotherapy. | 2022 May-Jun |
2 |
| 2 |
33529438 | Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells. | 2021 Aug |
1 |
| 3 |
33536335 | SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors. | 2021 Feb 9 |
1 |
| 4 |
31713291 | Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1. | 2020 May |
1 |
| 5 |
27634334 | DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer. | 2016 Sep 15 |
1 |
| 6 |
26055704 | hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. | 2015 Jul 24 |
1 |
| 7 |
26068472 | SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase. | 2015 Jul 27 |
1 |
| 8 |
24915421 | A novel small molecule hybrid of vorinostat and DACA displays anticancer activity against human hormone-refractory metastatic prostate cancer through dual inhibition of histone deacetylase and topoisomerase I. | 2014 Aug 1 |
1 |
| 9 |
24996846 | γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments. | 2014 Jul 4 |
2 |
| 10 |
25253693 | Gli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitors. | 2014 Nov 7 |
2 |
| 11 |
20042274 | ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. | 2010 Jun 28 |
1 |
| 12 |
19060337 | Dual regulation of Cdc25A by Chk1 and p53-ATF3 in DNA replication checkpoint control. | 2009 Feb 13 |
2 |
| 13 |
19716789 | The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. | 2009 Aug 28 |
1 |
| 14 |
18339864 | Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses. | 2008 Mar 15 |
1 |
| 15 |
18566216 | Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. | 2008 Jun |
2 |
| 16 |
17352464 | Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors. | 2007 Apr 5 |
3 |
| 17 |
17544271 | Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors. | 2007 Aug 1 |
1 |
| 18 |
17935989 | Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics. | 2007 Dec 1 |
1 |
| 19 |
17986860 | The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses. | 2007 Nov 15 |
1 |
| 20 |
16407843 | p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. | 2006 May 11 |
2 |
| 21 |
16603354 | 4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors. | 2006 Jun 15 |
1 |
| 22 |
16928813 | Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy. | 2006 Aug |
1 |
| 23 |
16928871 | The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. | 2006 Aug 23 |
2 |
| 24 |
15608676 | A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. | 2005 Feb 17 |
1 |
| 25 |
15665856 | The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. | 2005 Feb |
1 |
| 26 |
15699047 | The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. | 2005 Apr 8 |
1 |
| 27 |
16137618 | Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. | 2005 Sep 2 |
3 |
| 28 |
11980637 | Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. | 2002 May 1 |
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