Title : Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses.

Pub. Date : 2008 Mar 15

PMID : 18339864






1 Functional Relationships(s)
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1 Here, we found that the Hsp72-depleted cells show defect in phosphorylation and activation of the protein kinase Chk1 by genotoxic stresses, such as UVC irradiation or camptothecin. Camptothecin checkpoint kinase 1 Homo sapiens