Title : Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells.

Pub. Date : 2021 Aug

PMID : 33529438






1 Functional Relationships(s)
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1 In combination with cytotoxic chemotherapy such as gemcitabine or camptothecin, Chk1 inhibition increased cytoplasmic dsDNA compared to the cytotoxic alone but attenuated the cytotoxic chemotherapy-induced increase in IRF1 protein and STAT1 phosphorylation through inhibition of nuclear RelB translocation. Camptothecin checkpoint kinase 1 Homo sapiens