| 51 |
32317963 | Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo. | 2020 |
1 |
| 52 |
32408877 | Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity. | 2020 May 14 |
1 |
| 53 |
32410351 | Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema. | 2020 Aug 5 |
1 |
| 54 |
32435385 | Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels. | 2020 May 14 |
3 |
| 55 |
32449517 | Regulation of gene expression by MF63, a selective inhibitor of microsomal PGE synthase 1 (mPGES1) in human osteoarthritic chondrocytes. | 2020 Sep |
2 |
| 56 |
32576928 | DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1. | 2020 Jun 23 |
1 |
| 57 |
32583353 | What about COVID-19 and arachidonic acid pathway? | 2020 Nov |
1 |
| 58 |
32623799 | Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting. | 2020 Aug |
4 |
| 59 |
32655834 | miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. | 2020 Jun 30 |
3 |
| 60 |
32759273 | Microsomal Prostaglandin E2 Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice. | 2020 Oct |
2 |
| 61 |
33028694 | 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1. | 2020 Oct |
1 |
| 62 |
33233853 | Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics. | 2020 Nov 20 |
1 |
| 63 |
33273889 | Prostanoid Receptor Subtypes and Its Endogenous Ligands with Processing Enzymes within Various Types of Inflammatory Joint Diseases. | 2020 |
1 |
| 64 |
33408499 | Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. | 2020 |
1 |
| 65 |
33473256 | miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells. | 2020 Dec 22 |
2 |
| 66 |
30010723 | PGE2 increases inflammatory damage in Escherichia coli-infected bovine endometrial tissue in vitro via the EP4-PKA signaling pathway. | 2019 Jan 1 |
2 |
| 67 |
30349011 | Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women. | 2019 Sep |
2 |
| 68 |
30423474 | Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease. | 2019 Apr |
6 |
| 69 |
30506812 | Aminothiazoles inhibit osteoclastogenesis and PGE2 production in LPS-stimulated co-cultures of periodontal ligament and RAW 264.7 cells, and RANKL-mediated osteoclastogenesis and bone resorption in PBMCs. | 2019 Feb |
3 |
| 70 |
30537167 | A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors. | 2019 Jan 22 |
2 |
| 71 |
30538110 | The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma. | 2019 Mar 1 |
1 |
| 72 |
30814036 | MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. | 2019 Oct |
8 |
| 73 |
30867043 | Divergent roles of prostacyclin and PGE2 in human tendinopathy. | 2019 Mar 13 |
1 |
| 74 |
30879343 | CRISPR/Cas9-based liver-derived reporter cells for screening of mPGES-1 inhibitors. | 2019 Dec |
1 |
| 75 |
30897501 | Downregulation of microsomal prostaglandin E synthase-1 (mPGES-1) expression in chondrocytes is regulated by MAP kinase phosphatase-1 (MKP-1). | 2019 Jun |
1 |
| 76 |
30930248 | Regulatory roles of PGE2 in LPS-induced tissue damage in bovine endometrial explants. | 2019 Jun 5 |
1 |
| 77 |
30947012 | 5-Aminolevulinic Acid Suppresses Prostaglandin E2 Production by Murine Macrophages and Enhances Macrophage Cytotoxicity Against Glioma. | 2019 Jul |
1 |
| 78 |
31015404 | The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. | 2019 Apr 23 |
1 |
| 79 |
31059928 | Expression of enzymes involved in the synthesis of prostaglandin E2 in early- and late-cleaved bovine embryos at different stages of preimplantation development. | 2019 Jul 15 |
1 |
| 80 |
31136957 | Prostaglandin E2 promotes nitric oxide synthase 2, platelet-activating factor receptor, and matrix metalloproteinase-2 expression in Escherichia coli-challenged ex vivo endometrial explants via the prostaglandin E2 receptor 4/protein kinase a signaling pathway. | 2019 Aug |
2 |
| 81 |
31207300 | mPGES-1 as a new target to overcome acquired resistance to gefitinib in non-small cell lung cancer cell lines. | 2019 Aug |
1 |
| 82 |
31229523 | A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. | 2019 Oct |
2 |
| 83 |
31231223 | Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells. | 2019 |
1 |
| 84 |
31392591 | Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-Δ12,14-prostaglandin J2. | 2019 Oct |
1 |
| 85 |
31404942 | Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone. | 2019 Dec |
1 |
| 86 |
31638830 | Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier. | 2019 Dec |
4 |
| 87 |
28991413 | Ligand-based Modeling for the Prediction of Pharmacophore Features for Multi-targeted Inhibition of the Arachidonic Acid Cascade. | 2018 Mar |
2 |
| 88 |
29104159 | Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. | 2018 Jan |
3 |
| 89 |
29133047 | Discovery of new potent molecular entities able to inhibit mPGES-1. | 2018 Jan 1 |
1 |
| 90 |
29237778 | mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production. | 2018 Jan 15 |
5 |
| 91 |
29440395 | Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. | 2018 Apr 6 |
2 |
| 92 |
29456107 | Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1. | 2018 Mar 1 |
4 |
| 93 |
29458169 | Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice. | 2018 Jul |
4 |
| 94 |
29470537 | Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen. | 2018 |
2 |
| 95 |
29507686 | Mitochondrial oxidative stress activates COX-2/mPGES-1/PGE2 cascade induced by albumin in renal proximal tubular cells. | 2018 Feb 6 |
5 |
| 96 |
29511436 | Dihydroartemisinin inhibits indoxyl sulfate (IS)-promoted cell cycle progression in mesangial cells by targeting COX-2/mPGES-1/PGE2 cascade. | 2018 |
1 |
| 97 |
29569150 | Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder. | 2018 Aug |
3 |
| 98 |
29599139 | Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. | 2018 May |
7 |
| 99 |
29804818 | Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth. | 2018 Jun |
1 |
| 100 |
29891646 | mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress. | 2018 Aug |
4 |