| 1 |
34983695 | Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1. | 2022 Jan 4 |
2 |
| 2 |
33775835 | Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors. | 2021 Jun 1 |
1 |
| 3 |
33930567 | Pathophysiological role of prostaglandin E synthases in liver diseases. | 2021 Jun |
1 |
| 4 |
32317963 | Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo. | 2020 |
1 |
| 5 |
29891646 | mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress. | 2018 Aug |
1 |
| 6 |
27784694 | Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. | 2017 Jan 1 |
1 |
| 7 |
28675448 | Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition. | 2017 Nov |
1 |
| 8 |
26602278 | Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study. | 2016 Jan 1 |
1 |
| 9 |
27012893 | Insights into the structure activity relationship of mPGES-1 inhibitors: Hints for better inhibitor design. | 2016 Jul |
1 |
| 10 |
25961169 | Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics. | 2015 Jun 11 |
3 |
| 11 |
25988363 | Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2. | 2015 Jun 16 |
2 |
| 12 |
24756129 | Microsomal prostaglandin E synthase-1 deficiency exacerbates pulmonary fibrosis induced by bleomycin in mice. | 2014 Apr 21 |
2 |
| 13 |
25019142 | Inhibitors of microsomal prostaglandin E2 synthase-1 enzyme as emerging anti-inflammatory candidates. | 2014 Jul |
1 |
| 14 |
25453800 | Synthesis and PGE₂ production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells. | 2014 Dec 1 |
1 |
| 15 |
23789712 | Murine mPGES-1 3D structure elucidation and inhibitors binding mode predictions by homology modeling and site-directed mutagenesis. | 2013 Jul 22 |
1 |
| 16 |
24127557 | Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells. | 2013 Nov 15 |
1 |
| 17 |
22337655 | Lead discovery for microsomal prostaglandin E synthase using a combination of high-throughput fluorescent-based assays and RapidFire mass spectrometry. | 2012 Jun |
1 |
| 18 |
22588264 | Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results. | 2012 Jul |
1 |
| 19 |
20840544 | Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense. | 2011 Jan |
1 |
| 20 |
21266028 | mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. | 2011 |
1 |
| 21 |
22038016 | MK886 inhibits the proliferation of HL-60 leukemia cells by suppressing the expression of mPGES-1 and reducing prostaglandin E2 synthesis. | 2011 Nov |
2 |
| 22 |
20159030 | Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models. | 2010 Jun |
2 |
| 23 |
20369883 | Understanding microscopic binding of human microsomal prostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 and cofactor GSH: insights from computational alanine scanning and site-directed mutagenesis. | 2010 Apr 29 |
1 |
| 24 |
20371706 | Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness. | 2010 Jul |
1 |
| 25 |
18777160 | Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions. | 2009 Jan |
2 |
| 26 |
18984580 | Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. | 2009 Jan 2 |
1 |
| 27 |
19347995 | The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas. | 2009 Apr |
1 |
| 28 |
19426689 | Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. | 2009 May 1 |
1 |
| 29 |
18410593 | Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease. | 2008 May |
1 |
| 30 |
18626113 | HTRF-based assay for microsomal prostaglandin E2 synthase-1 activity. | 2008 Aug |
2 |
| 31 |
17049841 | Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages. | 2007 Jan |
1 |
| 32 |
17186945 | Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway. | 2007 Feb 23 |
1 |
| 33 |
16439136 | Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis. | 2006 May 15 |
2 |
| 34 |
16973753 | Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. | 2006 Sep 26 |
1 |
| 35 |
17023389 | Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis. | 2006 Nov |
1 |
| 36 |
15722356 | Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. | 2005 Apr 29 |
4 |
| 37 |
15899061 | Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2. | 2005 |
1 |
| 38 |
16128405 | Cyclooxygenases and prostaglandin E synthases in preimplantation mouse embryos. | 2005 May |
5 |
| 39 |
14871981 | Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis. | 2004 Feb 1 |
1 |
| 40 |
15047937 | Cyclooxygenases and prostaglandin E synthases in the endometrium of the rhesus monkey during the menstrual cycle. | 2004 Apr |
3 |
| 41 |
15225371 | Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. | 2004 |
1 |
| 42 |
15284079 | Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brain. | 2004 Nov |
1 |
| 43 |
12746259 | Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney. | 2003 Sep |
1 |
| 44 |
11795891 | Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages. | 2002 Jan 15 |
2 |
| 45 |
12233875 | Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells. | 2002 Sep |
2 |