Title : Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha.

Pub. Date : 2009 Jan 2

PMID : 18984580






1 Functional Relationships(s)
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Protein Name
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1 Interestingly, R126A and R126Q mPGES-1 exhibit a novel, glutathione-dependent, reductase activity, which allows conversion of prostaglandin H2 into prostaglandin F2alpha. Prostaglandin H2 prostaglandin E synthase Mus musculus