Title : Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis.

Pub. Date : 2004

PMID : 15225371






1 Functional Relationships(s)
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1 Conversion of PGH2 to PGE2 (PGES activity) was significantly increased in the lysate from IL-1beta-stimulated chondrocytes and it was inhibited by MK-886, which has an inhibitory effect on mPGES-1 activity. Prostaglandin H2 prostaglandin E synthase Mus musculus