ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate

toll-like receptor 4 ; Rattus norvegicus







75 Article(s)
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1 34913150 Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway. 2022 Feb 1
2 34923024 Protective effect of Toll-like receptor 4 antagonist on inflammation, EEG, and memory changes following febrile seizure in Wistar rats. 2022 Feb 26 2
3 34973529 Pharmacological inhibition of TLR4-NF-κB signaling by TAK-242 attenuates hydrocephalus after intraventricular hemorrhage. 2022 Feb 3
4 34975308 Early Toll-like receptor 4 inhibition improves immune dysfunction in the hippocampus after hypoxic-ischemic brain damage. 2022 1
5 35085701 The Toll-like receptor 4 antagonist TAK-242 induces antidepressant-like effects in a rat learned helplessness model of depression through BDNF-TrkB signaling and AMPA receptor activation. 2022 Apr 9 3
6 35345995 Qingchang mixture prevents the intestinal ischemia-reperfusion injury through TLR4/NF-kB pathway. 2022 Mar 28 1
7 35427564 Cordycepin ameliorates acute hypobaric hypoxia induced blood-brain barrier disruption, and cognitive impairment partly by suppressing the TLR4/NF-κB/MMP-9 pathway in the adult rats. 2022 Jun 5 1
8 35560852 Systematic analysis of critical genes and pathways identified a signature of neuropathic pain after spinal cord injury. 2022 May 12 3
9 33181267 Evidence that angiotensin II does not directly stimulate the MD2-TLR4 innate inflammatory pathway. 2021 Feb 1
10 33215215 Klotho attenuates angiotensin II‑induced cardiotoxicity through suppression of necroptosis and oxidative stress. 2021 Jan 1
11 33380567 Toll-like receptor 4/nuclear factor-kappa B pathway is involved in radicular pain by encouraging spinal microglia activation and inflammatory response in a rat model of lumbar disc herniation. 2021 Jan 1 1
12 33479186 Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway. 2021 Jan 21 1
13 33688227 Effects of Curcumin on High Glucose-Induced Epithelial-to-Mesenchymal Transition in Renal Tubular Epithelial Cells Through the TLR4-NF-κB Signaling Pathway. 2021 1
14 33758309 Astaxanthin protects against early acute kidney injury in severely burned rats by inactivating the TLR4/MyD88/NF-κB axis and upregulating heme oxygenase-1. 2021 Mar 23 1
15 34000276 N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway. 2021 Jul 1
16 34196587 Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway. 2021 Dec 1
17 34343528 Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats. 2021 Nov 2
18 34955133 [Protective effect of TAK242 blocking Toll-like receptor 4 pathway on septic myocardial injury and cardiac dysfunction]. 2021 Oct 5
19 31595494 Gestational diabetes mellitus affects odontoblastic differentiation of dental papilla cells via Toll-like receptor 4 signaling in offspring. 2020 Apr 1
20 32445868 Evolution of TLR4 role in mediating the hepatoprotective effects of estradiol after traumatic brain injury in male rats. 2020 Aug 1
21 32451779 Immuno-stimulatory capacity of decorin in the rat tail intervertebral disc and the mechanical consequence of resultant inflammation. 2020 Jul 1
22 32627010 TAK‑242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF‑κB signaling pathway in a neonatal hypoxic‑ischemic encephalopathy rat model. 2020 Aug 5
23 32653342 TLR4-TAK1-p38 MAPK pathway and HDAC6 regulate the expression of sigma-1 receptors in rat primary cultured microglia. 2020 Sep 2
24 32741952 Toll-Like Receptor 4 Inhibitor TAK-242 Augments Acetylcholine-Induced Relaxation in Superior Mesenteric Arteries of the Streptozotocin-Induced Diabetic Rat. 2020 1
25 32899630 Neuroprotection by Neurotropin through Crosstalk of Neurotrophic and Innate Immune Receptors in PC12 Cells. 2020 Sep 4 1
26 32956769 TLR4 inhibition ameliorates mesencephalic substantia nigra injury in neonatal rats exposed to lipopolysaccharide via regulation of neuro-immunity. 2020 Dec 2
27 32967743 TAK-242 Attenuates Crush Injury Induced Acute Kidney Injury through Inhibiting TLR4/NF-κB Signaling Pathways in Rats. 2020 Dec 1
28 29909454 Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4. 2019 Mar 1
29 30342113 Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. 2019 Jan 1
30 30414431 Metformin alleviates hyperglycemia-induced apoptosis and differentiation suppression in osteoblasts through inhibiting the TLR4 signaling pathway. 2019 Jan 1 1
31 30838902 Downregulation of glucose-6-phosphate dehydrogenase contributes to diabetic neuropathic pain through upregulation of toll-like receptor 4 in rats. 2019 Jan-Dec 1
32 31257518 TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats. 2019 Sep 2
33 31364129 Influences of the TLR4/NF-κB pathway on memory function and inflammatory factors in rats with cerebral small vessel disease. 2019 Jul 2
34 31432179 MicroRNA‑451 relieves inflammation in cerebral ischemia‑reperfusion via the Toll‑like receptor 4/MyD88/NF‑κB signaling pathway. 2019 Oct 2
35 31442443 Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity. 2019 Nov 2
36 31741857 Inhibitive effect of TAK-242 on Tenon's capsule fibroblasts proliferation in rat eyes. 2019 3
37 31933540 High-Fat Diet Aggravates the Intestinal Barrier Injury via TLR4-RIP3 Pathway in a Rat Model of Severe Acute Pancreatitis. 2019 1
38 29191677 Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling. 2018 Feb 1
39 29310498 Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine. 2018 Jan-Dec 1
40 29440462 miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN. 2018 Apr 27 1
41 29803222 Serum amyloid A primes microglia for ATP-dependent interleukin-1β release. 2018 May 26 1
42 29940584 Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury. 2018 2
43 30085340 Pro‑atherogenic activation of A7r5 cells induced by the oxLDL/β2GPI/anti‑β2GPI complex. 2018 Oct 1
44 30091424 Inhibition of Epidermal Growth Factor Receptor (EGFR) Reduces Lipopolysaccharide (LPS)-Induced Activation and Inflammatory Cytokines in Hepatic Stellate Cells In Vitro. 2018 Aug 9 3
45 30145096 Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats. 2018 Sep 1
46 30265151 Western diet triggers Toll-like receptor 4 signaling-induced endothelial dysfunction in female Wistar rats. 2018 Dec 1 1
47 30293084 Toll-Like Receptor 4 (TLR-4) Pathway Promotes Pulmonary Inflammation in Chronic Intermittent Hypoxia-Induced Obstructive Sleep Apnea. 2018 Oct 7 1
48 30572907 Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway. 2018 Dec 20 1
49 30585464 [Toll-like Receptor 4/Nuclear Factor-κB Signaling in Synovial Tissue Is Involved in the Anti-inflammatory Effect of Moxibustion in Rats with Rheumatoid Arthritis]. 2018 Nov 25 1
50 26961544 Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway. 2017 Jan 5