Title : TLR4 inhibition ameliorates mesencephalic substantia nigra injury in neonatal rats exposed to lipopolysaccharide via regulation of neuro-immunity.

Pub. Date : 2020 Dec

PMID : 32956769






2 Functional Relationships(s)
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1 We pre-treat neonatal rats with TAK-242, a TLR4 inhibitor, 1 day and 1 h before LPS injection to observe the neuroprotective effects on dopaminergic neurons of inhibition TLR4 in septic neonatal rats. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate toll-like receptor 4 Rattus norvegicus
2 We pre-treat neonatal rats with TAK-242, a TLR4 inhibitor, 1 day and 1 h before LPS injection to observe the neuroprotective effects on dopaminergic neurons of inhibition TLR4 in septic neonatal rats. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate toll-like receptor 4 Rattus norvegicus