Tyrosine

spleen associated tyrosine kinase ; Homo sapiens







424 Article(s)
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1 35079145 DOCK2 regulates antifungal immunity by regulating RAC GTPase activity. 2022 May 2
2 35535424 Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry. 2022 May 9 1
3 31949019 Low-dose Btk inhibitors selectively block platelet activation by CLEC-2. 2021 Jan 1 1
4 33455536 Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets. 2021 Jan 2 2
5 33472080 Critical role of Syk-dependent STAT1 activation in innate antiviral immunity. 2021 Jan 19 2
6 33535382 Tyrosine Phosphorylation Modulates Peroxiredoxin-2 Activity in Normal and Diseased Red Cells. 2021 Feb 1 4
7 33610045 Novel phospho-specific monoclonal antibodies reveal differential regulation of tyrosine phosphorylation within the immunoreceptor tyrosine-based activation motif of the Fc receptor γ subunit leading to fine tuning of Syk activation. 2021 Apr 2 3
8 33761438 Spleen tyrosine kinase regulates crosstalk of hypoxia-inducible factor-1α and nuclear factor (erythroid-derived2)-like 2 for B cell survival. 2021 Jun 1
9 34355656 The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy. 2021 Aug 6 1
10 34634301 Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling. 2021 Nov 2
11 30849265 Comparison of the GPVI inhibitors losartan and honokiol. 2020 1
12 31949205 Flavanomarein inhibits high glucose-stimulated epithelial-mesenchymal transition in HK-2 cells via targeting spleen tyrosine kinase. 2020 Jan 16 1
13 31974654 A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane. 2020 Dec 3
14 32015510 Inhibition of the deubiquitinase USP10 induces degradation of SYK. 2020 Apr 1
15 32205992 Role of spleen tyrosine kinase in liver diseases. 2020 Mar 14 1
16 32304729 Metabotropic signaling cascade involved in α4β2 nicotinic acetylcholine receptor-mediated PKCβII activation. 2020 Aug 1
17 32678160 BAFF attenuates oxidative stress-induced cell death by the regulation of mitochondria membrane potential via Syk activation in WiL2-NS B lymphoblasts. 2020 Jul 16 1
18 32926549 Effects of novel Btk and Syk inhibitors on platelet functions alone and in combination in vitro and in vivo. 2020 Dec 1
19 32977621 Syk Inhibitors: New Computational Insights into Their Intraerythrocytic Action in Plasmodium falciparum Malaria. 2020 Sep 23 1
20 33020271 Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A. 2020 Oct 20 1
21 33255747 The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. 2020 Nov 25 3
22 30465710 Synthetic biology of B cell activation: understanding signal amplification at the B cell antigen receptor using a rebuilding approach. 2019 Mar 26 4
23 30923129 A reevaluation of the spleen tyrosine kinase (SYK) activation mechanism. 2019 May 10 3
24 31145900 Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3. 2019 Jul 15 1
25 31216232 Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ. 2019 Aug 1 1
26 31362927 Interplay between HGAL and Grb2 proteins regulates B-cell receptor signaling. 2019 Aug 13 1
27 31519182 cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets. 2019 Sep 13 1
28 31649511 Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities. 2019 1
29 31817853 SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric ETV6-RUNX1 B-Acute Lymphoblastic Leukemia Patients. 2019 Dec 7 2
30 31817924 The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex. 2019 Dec 7 1
31 31881809 Feedback Regulation of Syk by Protein Kinase C in Human Platelets. 2019 Dec 25 3
32 29440271 Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms. 2018 Mar 30 5
33 29681901 Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy. 2018 1
34 30051939 Entropic allostery dominates the phosphorylation-dependent regulation of Syk tyrosine kinase release from immunoreceptor tyrosine-based activation motifs. 2018 Oct 1
35 30108111 Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis. 2018 Aug 14 1
36 30124011 [Investigation of the influence of mechanical signals on the structure of CD44/FERM complex via molecular dynamics simulation]. 2018 Aug 25 1
37 30203714 Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts. 2018 Sep 1
38 30217447 Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression. 2018 Oct 12 1
39 28275138 Distinct Expression and Function of FcεRII in Human B Cells and Monocytes. 2017 Apr 15 1
40 28283589 TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk. 2017 Mar 10 2
41 28634183 Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress. 2017 Aug 24 1
42 28736554 Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes. 2017 1
43 28760774 Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation. 2017 Nov 1 1
44 28767218 Selective Binders of the Tandem Src Homology 2 Domains in Syk and Zap70 Protein Kinases by DNA-Programmed Spatial Screening. 2017 Sep 20 1
45 28855374 Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics. 2017 Nov 7 6
46 28904407 Syk-dependent tyrosine phosphorylation of 3BP2 is required for optimal FcRγ-mediated phagocytosis and chemokine expression in U937 cells. 2017 Sep 13 5
47 28919467 Distribution of spleen tyrosine kinase and tau phosphorylated at tyrosine 18 in a mouse model of tauopathy and in the human hippocampus. 2017 Dec 15 2
48 29137391 Activated spleen tyrosine kinase promotes malignant progression of oral squamous cell carcinoma via mTOR/S6 signaling pathway in an ERK1/2-independent manner. 2017 Oct 13 1
49 29208681 HemITAM: A single tyrosine motif that packs a punch. 2017 Dec 5 1
50 26251216 Myeloid cell-mediated renal injury in rapidly progressive glomerulonephritis depends upon spleen tyrosine kinase. 2016 Jan 1