Title : DOCK2 regulates antifungal immunity by regulating RAC GTPase activity.

Pub. Date : 2022 May

PMID : 35079145






2 Functional Relationships(s)
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1 Mechanistically, after fungal stimulation, activated SYK (spleen-associated tyrosine kinase) phosphorylates DOCK2 at tyrosine 985 and 1405, which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation. Tyrosine spleen associated tyrosine kinase Homo sapiens
2 Mechanistically, after fungal stimulation, activated SYK (spleen-associated tyrosine kinase) phosphorylates DOCK2 at tyrosine 985 and 1405, which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation. Tyrosine spleen associated tyrosine kinase Homo sapiens