Title : The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets.

Pub. Date : 2020 Nov 25

PMID : 33255747






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Distinct membrane receptors activate platelets by Src-family-kinase (SFK)-, immunoreceptor-tyrosine-based-activation-motif (ITAM)-dependent stimulation of spleen tyrosine kinase (Syk). Tyrosine spleen associated tyrosine kinase Homo sapiens
2 Distinct membrane receptors activate platelets by Src-family-kinase (SFK)-, immunoreceptor-tyrosine-based-activation-motif (ITAM)-dependent stimulation of spleen tyrosine kinase (Syk). Tyrosine spleen associated tyrosine kinase Homo sapiens
3 Recently, we reported that platelet activation via glycoprotein (GP) VI or GPIbalpha stimulated the well-established Syk tyrosine (Y)-phosphorylation, but also stoichiometric, transient protein kinase C (PKC)-mediated Syk serine(S)297 phosphorylation in the regulatory interdomain-B, suggesting possible feedback inhibition. Tyrosine spleen associated tyrosine kinase Homo sapiens