ibrutinib

Bruton tyrosine kinase ; Homo sapiens







664 Article(s)
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601 24270740 BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity. 2014 Mar 3
602 24307721 Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia. 2014 Feb 20 4
603 24311722 Bruton's tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL). 2014 Feb 20 2
604 24332241 Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial. 2014 Jan 1
605 24338680 The promising impact of ibrutinib, a Bruton's tyrosine kinase inhibitor, for the management of lymphoid malignancies. 2014 Mar 3
606 24357428 Bruton's tyrosine kinase (BTK) inhibitors in clinical trials. 2014 Mar 3
607 24415539 Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy. 2014 Mar 20 2
608 24445187 Ibrutinib and indolent B-cell lymphomas. 2014 Aug 2
609 24472371 Ibrutinib for B cell malignancies. 2014 Jan 28 4
610 24481980 Ibrutinib in B-cell Lymphomas. 2014 Jun 2
611 24598688 [Ibrutinib in the treatment of chronic lymphocytic leukemia and other B-cell malignancies]. 2014 Feb 1
612 24612681 Bruton tyrosine kinase mediates TLR9-dependent human dendritic cell activation. 2014 Jun 2
613 24659631 Ibrutinib inhibits BCR and NF-κB signaling and reduces tumor proliferation in tissue-resident cells of patients with CLL. 2014 May 22 1
614 24693884 Different sensitivity of germinal center B cell-like diffuse large B cell lymphoma cells towards ibrutinib treatment. 2014 Apr 3 2
615 24697238 The bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) blocks hairy cell leukaemia survival, proliferation and B cell receptor signalling: a new therapeutic approach. 2014 Jul 4
616 24756799 Ibrutinib. 2014 1
617 24759210 Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor. 2014 Apr 24 1
618 24778403 Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies. 2014 Jun 10 1
619 24829205 Kinetics of CLL cells in tissues and blood during therapy with the BTK inhibitor ibrutinib. 2014 Jun 26 3
620 24869598 Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. 2014 Jun 12 8
621 24895895 Bruton's TK inhibitors: structural insights and evolution of clinical candidates. 2014 Apr 1
622 24918646 Ibrutinib for the treatment of chronic lymphocytic leukemia and mantle cell lymphoma. 2014 Apr 3
623 24957109 Characterization of ibrutinib-sensitive and -resistant mantle lymphoma cells. 2014 Sep 6
624 24970801 Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma. 2014 Jul 15 1
625 25026208 Ibrutinib treatment of CLL: the cancer fights back. 2014 Jul 14 2
626 25042202 Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study. 2014 Aug 1
627 25081321 Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells. 2014 Dec 1
628 25082755 Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma. 2014 Sep 9
629 25150798 Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study. 2014 Sep 2
630 25158606 Ibrutinib for the treatment of mantle cell lymphoma. 2014 Oct 1
631 25258342 IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells. 2014 Dec 4 1
632 25294819 Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML. 2014 Oct 30 2
633 25360238 Bruton's tyrosine kinase inhibitors and their clinical potential in the treatment of B-cell malignancies: focus on ibrutinib. 2014 Aug 2
634 25361916 Ibrutinib for the treatment of mantle cell lymphoma. 2014 Nov 1 2
635 25696845 BCR pathway inhibition as therapy for chronic lymphocytic leukemia and lymphoplasmacytic lymphoma. 2014 Dec 5 1
636 22975686 BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. 2013 Jan 3
637 23045577 Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. 2013 Jan 1 4
638 23296407 Ibrutinib (PCI-32765), the first BTK (Bruton's tyrosine kinase) inhibitor in clinical trials. 2013 Mar 3
639 23360303 The Bruton tyrosine kinase (BTK) inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse large-B cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells sensitive or resistant to bortezomib. 2013 Apr 4
640 23672610 Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases. 2013 Aug 2
641 23754751 Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells. 2013 Aug 2
642 23763320 [Inhibition of B cell receptor signaling: a first targeted therapeutic approach for chronic lymphocytic leukemia and other B cell lymphomas]. 2013 1
643 23782157 Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. 2013 Aug 8 2
644 23782158 Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. 2013 Jul 4 1
645 23940282 Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients. 2013 Oct 3 3
646 23954894 Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function. 2013 Oct 10 1
647 23958373 Ibrutinib and novel BTK inhibitors in clinical development. 2013 Aug 19 1
648 23962569 Bruton tyrosine kinase is commonly overexpressed in mantle cell lymphoma and its attenuation by Ibrutinib induces apoptosis. 2013 Oct 3
649 24014301 Towards targeted therapy of chronic lymphocytic leukemia. 2013 1
650 24083545 The emerging role of ibrutinib in the treatment of chronic lymphocytic leukemia. 2013 Oct 2