olaparib

BRCA1 DNA repair associated ; Homo sapiens







383 Article(s)
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1 34387603 Response to olaparib in metastatic lung adenocarcinoma with germline BRCA2 mutation: a case report. 2022 Jan 1 2
2 34799380 As Maintenance Therapy, Olaparib's Benefits Continue. 2022 Jan 1
3 34812730 Considerations on the identification and management of metastatic prostate cancer patients with DNA repair gene alterations in the Canadian context. 2022 Apr 1
4 34844775 Olaparib as first line in BRCA-mutated advanced ovarian carcinoma: Is it cost-effective in Spain? 2022 Feb 4
5 34854226 Deubiquitination of FBP1 by USP7 blocks FBP1-DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors. 2022 Apr 1
6 34887522 Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours. 2022 Apr 1
7 34954029 FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways. 2022 Jan 3
8 35051747 Recent advances in DDR (DNA damage response) inhibitors for cancer therapy. 2022 Feb 15 1
9 35074264 Olaparib Use in Patients With Metastatic Breast Cancer Harboring Somatic BRCA1/2 Mutations or Mutations in Non-BRCA1/2, DNA Damage Repair Genes. 2022 Jun 4
10 35085003 Exceptional Response to Olaparib and Pembrolizumab for Pancreatic Adenocarcinoma With Germline BRCA1 Mutation and High Tumor Mutation Burden: Case Report and Literature Review. 2022 Jan 1
11 35086955 Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers. 2022 Apr 1 1
12 35115180 Efficacy and safety of olaparib according to age in BRCA1/2-mutated patients with recurrent platinum-sensitive ovarian cancer: Analysis of the phase III SOLO2/ENGOT-Ov21 study. 2022 Apr 1
13 35146567 Olaparib for ovarian cancer: a single-institution, multi-site qualitative study. 2022 Jun 1
14 35147092 Sister Mary Joseph nodule as cutaneous manifestations of metastatic ovarian cancer: A case report and review of the literature. 2022 Feb 11 1
15 35153073 Second-line olaparib maintenance therapy is associated with poor response to subsequent chemotherapy in BRCA1/2-mutated epithelial ovarian cancer: A multicentre retrospective study. 2022 Apr 3
16 35156571 Durable Disease-Free Survival in a Patient with Metastatic Triple-Negative Breast Cancer Treated With Olaparib Monotherapy. 2022 Feb 14 1
17 35169388 Update Breast Cancer 2021 Part 4 - Prevention and Early Stages. 2022 Feb 1
18 35200549 An Unexpected Tumor Reduction: Treatment with Olaparib Monotherapy in Heavily Pretreated BRCA2 Mutated Metastatic Pancreatic Cancer. 2022 Jan 27 1
19 35290101 Olaparib With or Without Cediranib Versus Platinum-Based Chemotherapy in Recurrent Platinum-Sensitive Ovarian Cancer (NRG-GY004): A Randomized, Open-Label, Phase III Trial. 2022 Mar 15 5
20 35324529 Rapid and durable response to fifth-line lorlatinib plus olaparib in an ALK-rearranged, BRCA2-mutated metastatic lung adenocarcinoma patient with critical tracheal stenosis: a case report. 2022 Mar 23 1
21 35357078 Olaparib maintenance monotherapy in Chinese patients with platinum-sensitive relapsed ovarian cancer: China cohort from the phase III SOLO2 trial. 2022 Mar 31 1
22 35444023 Olaparib-induced cutaneous side effects in a patient with recurrent ovarian cancer. 2022 Apr 20 1
23 35511402 PARP Inhibition, a New Therapeutic Avenue in Patients with Prostate Cancer. 2022 May 1
24 35626017 Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer. 2022 May 13 5
25 33012578 Efficacy of PARP Inhibition in Metastatic Castration-resistant Prostate Cancer is Very Different with Non-BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B from the Phase 3 PROfound Trial of Olaparib. 2021 Apr 1
26 33069804 Folliculin deficient renal cancer cells exhibit BRCA1 A complex expression impairment and sensitivity to PARP1 inhibitor olaparib. 2021 Feb 15 1
27 33094666 An evaluation of olaparib for the treatment of pancreatic cancer. 2021 Mar 1
28 33236159 PARP inhibitor resistance and TP53 mutations in patients treated with olaparib for BRCA-mutated cancer: Four case reports. 2021 Jan 4
29 33250205 Olaparib maintenance therapy in patients with newly diagnosed advanced ovarian cancer and a BRCA1 and/or BRCA2 mutation: SOLO1 China cohort. 2021 Jan 2
30 33268569 Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer. 2021 Feb 1
31 33301768 Droplet digital PCR for large genomic rearrangements detection: A promising strategy in tissue BRCA1 testing. 2021 Feb 1
32 33341987 Poly(ADP-ribose) polymerase inhibition in pancreatic cancer. 2021 May 1
33 33382149 PARP inhibitors in ovarian cancer: An overview of the practice-changing trials. 2021 May 1
34 33407459 A novel somatic BRCA2 point mutation in a metastatic pancreatic cancer patient: a case report. 2021 Jan 6 1
35 33432021 A comprehensive analysis of somatic alterations in Chinese ovarian cancer patients. 2021 Jan 11 1
36 33468723 [Effects of Olaparib, a PARP-1 Inhibitor, on Triple Negative Breast Cancer Cells with a BRCA1 Mutation]. 2021 Jan 3
37 33513287 Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors. 2021 Apr 1
38 33546874 [Drug approval: Olaparib - metastatic castration-resistant prostate cancer with BRCA mutation]. 2021 Feb 1
39 33559413 A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01). 2021 Mar 3
40 33592660 [Diagnostics and therapy of pancreatic carcinoma]. 2021 Feb 2
41 33617901 Patient-derived xenograft models of BRCA-associated pancreatic cancers. 2021 Apr 1
42 33627685 A phase I dose-finding, pharmacokinetics and genotyping study of olaparib and lurbinectedin in patients with advanced solid tumors. 2021 Feb 24 1
43 33637776 BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. 2021 Feb 26 2
44 33662100 Olaparib Monotherapy for Previously Treated Pancreatic Cancer With DNA Damage Repair Genetic Alterations Other Than Germline BRCA Variants: Findings From 2 Phase 2 Nonrandomized Clinical Trials. 2021 May 1 1
45 33710534 An Overview of PARP Inhibitors for the Treatment of Breast Cancer. 2021 May 1
46 33742489 Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. 2021 Jul 1
47 33743851 Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial. 2021 May 1
48 33767780 The role of novel poly (ADP-ribose) inhibitors in the treatment of locally advanced and metastatic Her-2/neu negative breast cancer with inherited germline BRCA1/2 mutations. A review of the literature. 2021 Jan-Mar 2
49 33803939 Candidate Markers of Olaparib Response from Genomic Data Analyses of Human Cancer Cell Lines. 2021 Mar 15 1
50 33827356 Olaparib and rucaparib for the treatment of DNA repair-deficient metastatic castration-resistant prostate cancer. 2021 Aug 1