Title : Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody-drug Conjugate Targeting AXL-expressing Cancers.

Pub. Date : 2022 Apr 1

PMID : 35086955






1 Functional Relationships(s)
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1 Notably, ADCT-601 had antitumor activity in a monomethyl auristatin E-resistant lung-cancer model and synergized with the poly ADP-ribose polymerase-inhibitor olaparib in a BRCA1-mutated ovarian cancer model. olaparib BRCA1 DNA repair associated Homo sapiens