Paclitaxel

BRCA1 DNA repair associated ; Homo sapiens







41 Article(s)
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1 35105904 Ovarian toxicity of carboplatin and paclitaxel in mouse carriers of mutation in BRIP1 tumor suppressor gene. 2022 Feb 1 1
2 33319669 Resistance to Intervention: Paclitaxel in Breast Cancer. 2021 1
3 33377156 Value of adjuvant chemotherapy and informed microscopic examination for occult gynecologic cancer detected upon risk-reducing salpingo-oophorectomy after chemotherapy for BRCA1/2-associated breast cancer: a case report. 2021 Mar 3 1
4 33859743 Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer. 2021 1
5 33996534 The Efficacy of Combined Cisplatin and Nanoparticle Albumin-Bound Paclitaxel in a Stage IV Pancreatic Squamous Cell Carcinoma Patient With a Somatic BRCA2 Mutation: A Case Report. 2021 1
6 32194804 Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets. 2020 1
7 32724113 Patient-derived ovarian cancer organoids capture the genomic profiles of primary tumours applicable for drug sensitivity and resistance testing. 2020 Jul 28 1
8 32861273 Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial. 2020 Oct 1
9 33457057 Incidence of Hypersensitivity Reactions to Carboplatin or Paclitaxel in Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer With or Without BRCA1 or BRCA2 Mutations. 2019 Jul 3
10 29189915 Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations. 2018 Feb 1
11 27739325 A randomized Phase II study of veliparib with temozolomide or carboplatin/paclitaxel versus placebo with carboplatin/paclitaxel in BRCA1/2 metastatic breast cancer: design and rationale. 2017 Feb 1
12 28604461 Chemosensitivity of BRCA1-Mutated Ovarian Cancer Cells and Established Cytotoxic Agents. 2017 Oct 1
13 27113739 Neo-adjuvant doxorubicin and cyclophosphamide followed by paclitaxel in triple-negative breast cancer among BRCA1 mutation carriers and non-carriers. 2016 May 2
14 25445425 Triple negative breast cancer in BRCA1 mutation carriers with a complete radiologic response to neoadjuvant paclitaxel: a case report. 2015 Apr 1
15 25481791 Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial. 2015 Jan 1
16 25499884 Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells. 2015 Aug 1 4
17 25583261 BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. 2015 Jan 13 8
18 24847251 Strong and Sustained Response to Treatment with Carboplatin plus Nab-Paclitaxel in a Patient with Metastatic, Triple-Negative, BRCA1-Positive Breast Cancer. 2014 Jan 1
19 23265709 Implications of BRCA1 and BRCA2 mutations for the efficacy of paclitaxel monotherapy in advanced ovarian cancer. 2013 Apr 1
20 23326344 BRCA1 mRNA expression as a predictive and prognostic marker in advanced esophageal squamous cell carcinoma treated with cisplatin- or docetaxel-based chemotherapy/chemoradiotherapy. 2013 1
21 23462720 BRCA1 expression and improved survival in ovarian cancer patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study. 2013 Apr 2 2
22 23522120 Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient. 2013 Mar 22 1
23 23964347 Assessment of the Prognostic Value of Two Common Variants of BRCA1 and BRCA2 Genes in Ovarian Cancer Patients Treated with Cisplatin and Paclitaxel: A Gynecologic Oncology Group Study. 2013 1
24 21296416 BRCA1 suppresses the expression of survivin and promotes sensitivity to paclitaxel through the calcium sensing receptor (CaSR) in human breast cancer cells. 2011 Feb 8
25 21781528 [The correlation between chemotherapeutic efficacy and breast cancer susceptibility gene 1 and class IIIβ-tubulin protein expression in non-small cell lung cancer patients]. 2011 Jun 1
26 19442054 A systematic review of genes involved in the inverse resistance relationship between cisplatin and paclitaxel chemotherapy: role of BRCA1. 2009 May 1
27 19551867 BRCA1 modulates malignant cell behavior, the expression of survivin and chemosensitivity in human breast cancer cells. 2009 Dec 15 5
28 19697632 Repeat chemosensitivity of epithelial ovarian carcinoma in a BRCA1 mutation carrier to paclitaxel/platinum combination chemotherapy. 2009 3
29 19955925 Does paclitaxel-carboplatin chemotherapy in a dose-dense regimen enhance survival of BRCA-related ovarian cancer patients? 2009 Dec 1
30 18547621 Xenografts of primary human gynecological tumors grown under the renal capsule of NOD/SCID mice show genetic stability during serial transplantation and respond to cytotoxic chemotherapy. 2008 Aug 1
31 19002265 Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. 2008 1
32 19690636 BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer Cells. 2007 Mar 2 1
33 16639080 BRCA1 downregulation leads to premature inactivation of spindle checkpoint and confers paclitaxel resistance. 2006 May 7
34 16982732 A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. 2006 Sep 15 3
35 15607317 Development and applications of a real-time quantitative RT-PCR method (QRT-PCR) for BRCA1 mRNA. 2005 Jan 1
36 12717416 Role of BRCA1 in cellular resistance to paclitaxel and ionizing radiation in an ovarian cancer cell line carrying a defective BRCA1. 2003 Apr 24 4
37 14559807 BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. 2003 Oct 1 1
38 11295099 Regulation of BRCA1 and BRCA2 transcript in response to cisplatin, adriamycin, taxol and ionising radiation is correlated to p53 functional status in ovarian cancer cell lines. 2001 May-Jun 1
39 11562742 Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells. 2001 Oct 1
40 11593420 BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents. 2001 Sep 27 2
41 11641785 Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. 2001 Oct 4 1