Title : A mouse model for the molecular characterization of brca1-associated ovarian carcinoma.

Pub. Date : 2006 Sep 15

PMID : 16982732






3 Functional Relationships(s)
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1 Consistent with the reported platinum chemosensitivity in patients with Brca1-associated ovarian cancer, the Brca1-deficient OSE cells have increased sensitivity to the DNA-damaging agent cisplatin, whereas sensitivity to the microtubule poison paclitaxel is similar between Brca1 wild-type and Brca1-deficient cells. Paclitaxel BRCA1 DNA repair associated Homo sapiens
2 Consistent with the reported platinum chemosensitivity in patients with Brca1-associated ovarian cancer, the Brca1-deficient OSE cells have increased sensitivity to the DNA-damaging agent cisplatin, whereas sensitivity to the microtubule poison paclitaxel is similar between Brca1 wild-type and Brca1-deficient cells. Paclitaxel BRCA1 DNA repair associated Homo sapiens
3 Consistent with the reported platinum chemosensitivity in patients with Brca1-associated ovarian cancer, the Brca1-deficient OSE cells have increased sensitivity to the DNA-damaging agent cisplatin, whereas sensitivity to the microtubule poison paclitaxel is similar between Brca1 wild-type and Brca1-deficient cells. Paclitaxel BRCA1 DNA repair associated Homo sapiens