Pub. Date : 2011 Feb
PMID : 21296416
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BRCA1 suppresses the expression of survivin and promotes sensitivity to paclitaxel through the calcium sensing receptor (CaSR) in human breast cancer cells. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 2 | Both BRCA1 and CaSR have been shown to suppress the expression of survivin and promote sensitivity to paclitaxel in human breast cancer cells. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 3 | We found that mutant cells (harboring mutant BRCA1 with loss of BRCA1 expression) had a significant reduction in the expression of CaSR with a concurrent up-regulated expression of survivin and were resistant to paclitaxel by comparison to wild type cells (harboring wild type BRCA1 and expressing BRCA1). | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 4 | Knocking down the expression of BRCA1 in wild type cells resulted in a reduction in CaSR expression with a concurrent up-regulated expression of survivin and reduction in sensitivity to paclitaxel. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 5 | Re-expression of BRCA1 in BRCA1 knocked-down wild type cells restored CaSR expression with a concurrent down-regulated expression of survivin and restoration of sensitivity to paclitaxel. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 6 | Re-expression of BRCA1 in BRCA1 knocked-down wild type cells restored CaSR expression with a concurrent down-regulated expression of survivin and restoration of sensitivity to paclitaxel. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 7 | Corollary, ectopic expression of BRCA1 in mutant cells induced CaSR expression, suppressed the expression of survivin and restored sensitivity to paclitaxel. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |
| 8 | We conclude, and report for the first time, that BRCA1 regulates the expression of CaSR and that it functions through CaSR in suppressing the expression of survivin and promoting sensitivity to paclitaxel. | Paclitaxel | BRCA1 DNA repair associated | Homo sapiens |