Title : BRCA1 and GADD45 mediated G2/M cell cycle arrest in response to antimicrotubule agents.

Pub. Date : 2001 Sep 27

PMID : 11593420






2 Functional Relationships(s)
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1 Induction of BRCA1 in the presence of Taxol and Vincristine resulted in a dramatic increase in cell death; an effect that was preceded by an acute arrest at the G2/M phase of the cell cycle and which correlated with BRCA1 mediated induction of GADD45. Paclitaxel BRCA1 DNA repair associated Homo sapiens
2 Induction of BRCA1 in the presence of Taxol and Vincristine resulted in a dramatic increase in cell death; an effect that was preceded by an acute arrest at the G2/M phase of the cell cycle and which correlated with BRCA1 mediated induction of GADD45. Paclitaxel BRCA1 DNA repair associated Homo sapiens