Guanosine Triphosphate

eukaryotic translation elongation factor 1 alpha 1 ; Homo sapiens







110 Article(s)
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Pub. Year
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1 34203525 On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits. 2021 Jun 28 1
2 31711607 tRNA Dissociation from EF-Tu after GTP Hydrolysis: Primary Steps and Antibiotic Inhibition. 2020 Jan 7 5
3 32024753 Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection. 2020 Feb 18 4
4 30370994 The role of translation elongation factor eEF1 subunits in neurodevelopmental disorders. 2019 Feb 2
5 31058500 Elongation Factor Tu's Nucleotide Binding Is Governed by a Thermodynamic Landscape Unique among Bacterial Translation Factors. 2019 Jul 3 4
6 29417736 mRNA-Independent way to regulate translation elongation rate in eukaryotic cells. 2018 Mar 2
7 29459784 2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation. 2018 Mar 2
8 29792818 Substrate-Induced Formation of Ribosomal Decoding Center for Accurate and Rapid Genetic Code Translation. 2018 May 20 2
9 30108131 Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2. 2018 Sep 1 1
10 28108655 The novel lysine specific methyltransferase METTL21B affects mRNA translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A). 2017 May 5 1
11 29045140 The Conformational Change in Elongation Factor Tu Involves Separation of Its Domains. 2017 Nov 14 2
12 26653849 Theoretical Insights on the Mechanism of the GTP Hydrolysis Catalyzed by the Elongation Factor Tu (EF-Tu). 2016 Jan 14 3
13 25566871 A conserved P-loop anchor limits the structural dynamics that mediate nucleotide dissociation in EF-Tu. 2015 Jan 8 3
14 26073967 Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu. 2015 Jul 3
15 26651998 Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. 2015 Dec 10 1
16 24564225 An evolutionary ratchet leading to loss of elongation factors in eukaryotes. 2014 Feb 24 2
17 24990941 Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex. 2014 Aug 22 4
18 25225612 A monovalent cation acts as structural and catalytic cofactor in translational GTPases. 2014 Nov 3 1
19 25246550 Ribosome-induced tuning of GTP hydrolysis by a translational GTPase. 2014 Oct 7 4
20 25326326 Mammalian translation elongation factor eEF1A2: X-ray structure and new features of GDP/GTP exchange mechanism in higher eukaryotes. 2014 Nov 10 5
21 25436608 Characterisation of translation elongation factor eEF1B subunit expression in mammalian cells and tissues and co-localisation with eEF1A2. 2014 2
22 23864225 Mechanism of activation of elongation factor Tu by ribosome: catalytic histidine activates GTP by protonation. 2013 Sep 5
23 22378069 Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells. 2012 Mar 1 1
24 22437501 A new understanding of the decoding principle on the ribosome. 2012 Mar 21 1
25 22459262 Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesis. 2012 Jun 8 2
26 22740700 Thermodynamics of the GTP-GDP-operated conformational switch of selenocysteine-specific translation factor SelB. 2012 Aug 10 2
27 20838377 Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis. 2011 Jan 20 2
28 21665947 Mitotic modulation of translation elongation factor 1 leads to hindered tRNA delivery to ribosomes. 2011 Aug 12 1
29 21719661 Comment on "The mechanism for activation of GTP hydrolysis on the ribosome". 2011 Jul 1 5
30 20434456 Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome. 2010 Jun 18 1
31 21051640 The mechanism for activation of GTP hydrolysis on the ribosome. 2010 Nov 5 3
32 19833920 The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA. 2009 Oct 30 4
33 18336835 Dynamics of Recognition between tRNA and elongation factor Tu. 2008 Apr 11 1
34 18773979 Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu. 2008 Dec 11
35 18789156 A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu. 2008 Sep 12 2
36 17397188 Mechanism of EF-Ts-catalyzed guanine nucleotide exchange in EF-Tu: contribution of interactions mediated by helix B of EF-Tu. 2007 May 1 2
37 17951333 Thiostrepton inhibition of tRNA delivery to the ribosome. 2007 Dec 3
38 16601123 SmpB triggers GTP hydrolysis of elongation factor Tu on ribosomes by compensating for the lack of codon-anticodon interaction during trans-translation initiation. 2006 Jun 9 2
39 16717093 The importance of P-loop and domain movements in EF-Tu for guanine nucleotide exchange. 2006 Jul 28 2
40 16876786 Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action. 2006 Aug 21 1
41 17033963 Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs. 2006 Nov 1
42 17042495 Delayed release of inorganic phosphate from elongation factor Tu following GTP hydrolysis on the ribosome. 2006 Oct 24 3
43 15680978 Recognition and selection of tRNA in translation. 2005 Feb 7 1
44 15004548 Streptomycin interferes with conformational coupling between codon recognition and GTPase activation on the ribosome. 2004 Apr 4
45 15033564 eEF1A binding to aminoacylated viral RNA represses minus strand synthesis by TYMV RNA-dependent RNA polymerase. 2004 Mar 30 7
46 15109577 Chaperone-like activity of mammalian elongation factor eEF1A: renaturation of aminoacyl-tRNA synthetases. 2004 Jul 2
47 15317456 Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products. 2004 Aug 26 3
48 15581367 Effects of the antibiotic pulvomycin on the elongation factor Tu-dependent reactions. Comparison with other antibiotics. 2004 Dec 14 6
49 16120370 Interaction of mitochondrial elongation factor Tu with aminoacyl-tRNAs. 2004 Jun 2
50 12618188 EF-Tu binding peptides identified, dissected, and affinity optimized by phage display. 2003 Feb 2