Pub. Date : 2008 Dec
PMID : 18773979
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 2 | Mechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor Tu. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 3 | Elongation factor Tu (EF-Tu), the protein responsible for delivering aminoacyl-tRNAs (aa-tRNAs) to ribosomal A site during translation, belongs to the group of guanosine-nucleotide (GTP/GDP) binding proteins. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 4 | Elongation factor Tu (EF-Tu), the protein responsible for delivering aminoacyl-tRNAs (aa-tRNAs) to ribosomal A site during translation, belongs to the group of guanosine-nucleotide (GTP/GDP) binding proteins. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 5 | In the first case we presumably mimic binding of the ternary complex EF-Tu.GTP.aa-tRNA to the ribosome and allow the histidine (His85) side chain of the protein to approach the reaction active site. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 6 | In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP+H(2)O-->GDP+Pi proceeds without participation of the histidine but through water molecules. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 7 | In the second case, corresponding to the GTP hydrolysis by EF-Tu alone, the side chain of His85 stays away from the active site, and the chemical reaction GTP+H(2)O-->GDP+Pi proceeds without participation of the histidine but through water molecules. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 8 | In agreement with the experimental observations which distinguish rate constants for the fast chemical reaction in EF-Tu.GTP.aa-tRNA.ribosome and the slow spontaneous GTP hydrolysis in EF-Tu, we show that the activation energy barrier for the first scenario is considerably lower compared to that of the second case. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 9 | In agreement with the experimental observations which distinguish rate constants for the fast chemical reaction in EF-Tu.GTP.aa-tRNA.ribosome and the slow spontaneous GTP hydrolysis in EF-Tu, we show that the activation energy barrier for the first scenario is considerably lower compared to that of the second case. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 10 | In agreement with the experimental observations which distinguish rate constants for the fast chemical reaction in EF-Tu.GTP.aa-tRNA.ribosome and the slow spontaneous GTP hydrolysis in EF-Tu, we show that the activation energy barrier for the first scenario is considerably lower compared to that of the second case. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 11 | In agreement with the experimental observations which distinguish rate constants for the fast chemical reaction in EF-Tu.GTP.aa-tRNA.ribosome and the slow spontaneous GTP hydrolysis in EF-Tu, we show that the activation energy barrier for the first scenario is considerably lower compared to that of the second case. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |