Pub. Date : 2014 Oct 7
PMID : 25246550
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 2 | GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 3 | Here we use mutational analysis in combination with measurements of rate/pH profiles, kinetic solvent isotope effects, and ion dependence of GTP hydrolysis by EF-Tu off and on the ribosome to dissect the reaction mechanism. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |
| 4 | In contrast, upon cognate codon recognition, the ribosome induces a rearrangement of EF-Tu that renders GTP hydrolysis sensitive to mutations of Asp21 and His84 and insensitive to K(+) ions. | Guanosine Triphosphate | eukaryotic translation elongation factor 1 alpha 1 | Homo sapiens |