Iron

hypoxia inducible factor 1 subunit alpha ; Homo sapiens







137 Article(s)
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51 22281055 Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture. 2012 Mar 5
52 22453918 The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). 2012 May 18 1
53 22938093 Structures and mechanisms of antitumor agents: xestoquinones uncouple cellular respiration and disrupt HIF signaling in human breast tumor cells. 2012 Sep 28 2
54 21368293 Hypoxia. 5. Hypoxia and hematopoiesis. 2011 Jun 1
55 21861815 Hypoxia inducible factor-1 as a target for neurodegenerative diseases. 2011 1
56 21907923 The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels. 2011 Sep 13 1
57 19861159 Oxygen-sensing under the influence of nitric oxide. 2010 Mar 2
58 20023006 Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. 2010 Mar 3
59 20095867 Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities. 2010 Sep 15 6
60 20416277 Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases. 2010 May 28 1
61 20546814 Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. 2010 Oct 5
62 20711226 Hypoxia inducible factor 1 (HIF-1) and cardioprotection. 2010 Sep 2
63 20723262 Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis. 2010 Aug 19 4
64 20929261 Mammea E/BB, an isoprenylated dihydroxycoumarin protonophore that potently uncouples mitochondrial electron transport, disrupts hypoxic signaling in tumor cells. 2010 Nov 29 2
65 19074761 Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. 2009 Feb 3
66 19263519 Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: implication in manganese-induced pulmonary inflammation. 2009 Mar 15 1
67 19384570 Non-hypoxic stabilization of hypoxia-inducible factor alpha (HIF-alpha): relevance in neural progenitor/stem cells. 2009 May 2
68 19729006 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. 2009 Dec 1
69 17973296 Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. 2008 Apr 15 4
70 18061585 Flavonoids induce HIF-1alpha but impair its nuclear accumulation and activity. 2008 Feb 15 2
71 18245813 Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. 2008 Mar 1
72 18261897 DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension. 2008 Mar 1
73 18371939 Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1alpha stabilization in the host brain. 2008 May 1 1
74 18385176 Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha. 2008 Aug 2
75 18459142 PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress. 2008 Aug 15 1
76 18538129 Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. 2008 Aug 8 2
77 18559422 Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia. 2008 Aug 1
78 18809098 Erythropoietic agents and the elderly. 2008 Oct 1
79 19076458 Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. 2008 Dec 1
80 17364964 The flavonoid quercetin induces hypoxia-inducible factor-1alpha (HIF-1alpha) and inhibits cell proliferation by depleting intracellular iron. 2007 Mar 1
81 17377063 Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase. 2007 Jun 2
82 16139409 Differential responses of two degradation domains of HIF-1alpha to hypoxia and iron deficiency. 2006 Feb 4
83 16510596 Effects of transferrin receptor blockade on cancer cell proliferation and hypoxia-inducible factor function and their differential regulation by ascorbate. 2006 Mar 1 1
84 16527254 Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway. 2006 Apr 28 3
85 16773207 A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent. 2006 Jul 1
86 16842166 Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1). 2006 1
87 16877034 Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells. 2006 Nov 7 2
88 17015263 Cobalt induces hypoxia-inducible factor-1alpha (HIF-1alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism. 2006 Aug 3
89 17100286 [HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia]. 2006 Mar-Apr 1
90 17168739 Role of HIF-1 in iron regulation: potential therapeutic strategy for neurodegenerative disorders. 2006 Dec 1
91 17178876 Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1. 2006 Dec 15 2
92 17190448 Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells. 2006 Dec 1
93 15538748 Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation. 2005 May 15 1
94 15749641 [Hypoxia-inducible factor 1: regulation, involvement in carcinogenesis and target for anticancer therapy]. 2005 Feb 1
95 15777842 The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL. 2005 Mar 22 1
96 15878351 Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron. 2005 May 15 1
97 15885310 Vascular endothelial growth factor is regulated by hypoxic stress via MAPK and HIF-1 alpha in the inner ear. 2005 Jun 1
98 15897903 Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion. 2005 Jul 14 2
99 15913932 Hypoxia-induced IL-6 production is associated with activation of MAP kinase, HIF-1, and NF-kappaB on HEI-OC1 cells. 2005 Sep 1
100 15923604 Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. 2005 Jun 1