Title : Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Pub. Date : 2008 Dec

PMID : 19076458






1 Functional Relationships(s)
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1 Our group and others have implicated the transcriptional activator HIF-1 in some of the salutary effects of iron chelation-induced PHD inhibition. Iron hypoxia inducible factor 1 subunit alpha Homo sapiens