Title : The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.

Pub. Date : 2011 Sep 13

PMID : 21907923






1 Functional Relationships(s)
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1 Reduced AMPK levels lead to diminished expression of the DMT1 iron transporter, and the resulting cytosolic iron deficiency activates the iron regulatory proteins, IRP1 and IRP2, and increases expression of the hypoxia inducible factor HIF-1alpha, but not HIF-2alpha. Iron hypoxia inducible factor 1 subunit alpha Homo sapiens