Title : The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.

Pub. Date : 2005 Mar 22

PMID : 15777842






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Enzymes of this class, such as prolyl-4-hydroxylases, mediate the oxygen and iron-dependent degradation of the hypoxia inducible factor HIF-1alpha, which requires the E3 ubiquitin ligase activity of pVHL. Iron hypoxia inducible factor 1 subunit alpha Homo sapiens