Pub. Date : 2018 Aug
PMID : 29659168
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also indicate that metformin increases the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2), which binds to the antioxidant response elements in the GPX7 gene promoter to induce its expression. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | We also indicate that metformin increases the nuclear accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2), which binds to the antioxidant response elements in the GPX7 gene promoter to induce its expression. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Moreover, the metformin-Nrf2-GPx7 pathway delays aging in worms. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Our study provides mechanistic insights into the beneficial effects of metformin on human cellular aging and highlights the importance of the Nrf2-GPx7 pathway in pro-longevity signaling. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |