Pub. Date : 2020 Sep
PMID : 32863218
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Further investigation confirmed that nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor managing antioxidative function, and its downstream antioxidant detoxifying enzyme were activated by metformin, resulting in the inhibition of the Pb-caused oxidative stress. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Further investigation confirmed that nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor managing antioxidative function, and its downstream antioxidant detoxifying enzyme were activated by metformin, resulting in the inhibition of the Pb-caused oxidative stress. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Moreover, Nrf2 mediated the protection of metformin against mitochondrial fragmentation induced by Pb exposure, while knockdown of Nrf2 abrogated the protective effect. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | To conclude, metformin could ameliorate Pb-induced mitochondrial fragmentation via antioxidative effects originated from AMPK/Nrf2 pathway activation, promoting energy supply and cell survival. | Metformin | NFE2 like bZIP transcription factor 2 | Homo sapiens |