Sirolimus

ribosomal protein S6 kinase B1 ; Homo sapiens







298 Article(s)
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201 15632115 Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid. 2005 Mar 18 1
202 15659381 Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. 2005 Mar 25 2
203 15677443 The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 2005 Apr 8 1
204 15696050 Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. 2005 Jan 2
205 15715661 Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. 2005 Mar 2
206 15882288 Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability. 2005 Jun 2
207 15895362 Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells. 2005 Dec 1
208 15914125 Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53. 2005 Jun 1 1
209 16018822 Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells. 2005 Jul 15 1
210 16139919 Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. 2005 Dec 1
211 16255777 Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin. 2005 Oct 28 1
212 14560955 TOR action in mammalian cells and in Caenorhabditis elegans. 2004 5
213 14871980 Determinants of rapamycin sensitivity in breast cancer cells. 2004 Feb 1 2
214 14970836 Inhibition of insulin signaling and adipogenesis by rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1. 2004 Feb 2
215 15016873 High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein. 2004 Apr 1
216 15070696 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. 2004 Apr 15 2
217 15208659 L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway. 2004 Aug 12 3
218 15213227 Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. 2004 Aug 27 1
219 15235105 Both mitogen-activated protein kinase and phosphatidylinositol 3-kinase signalling are required in epidermal growth factor-induced human trophoblast migration. 2004 Sep 1
220 15520200 Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. 2004 Nov 1 1
221 15561916 Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. 2004 Dec 1
222 15623621 mTOR and P70 S6 kinase expression in primary liver neoplasms. 2004 Dec 15 2
223 12668683 Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland. 2003 Jun 13 1
224 12681504 Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QM7 myoblasts. 2003 Apr 10 1
225 12704019 Beta-adrenergic agonists regulate Na-K-ATPase via p70S6k. 2003 Oct 1
226 12740386 Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase. 2003 Jul 25 2
227 12773160 The tuberous sclerosis complex (TSC) pathway and mechanism of size control. 2003 Jun 1
228 12906785 Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. 2003 Aug 5 1
229 12935893 Rapamycin inhibits GM-CSF-induced neutrophil migration. 2003 Aug 28 2
230 12949840 Involvement of the Akt/mTOR pathway on EGF-induced cell transformation. 2003 Sep 2
231 11914378 Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. 2002 May 31 3
232 11967149 Identification of a conserved motif required for mTOR signaling. 2002 Apr 16 3
233 12032842 Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway. 2002 May 23 1
234 12045200 Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). 2002 Aug 23 1
235 12054624 Molecular crosstalk between p70S6k and MAPK cell signaling pathways. 2002 Apr 26 1
236 12080086 Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. 2002 Jun 15 1
237 12176053 Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells. 2002 Sep 1 1
238 12183455 Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. 2002 Oct 25 1
239 12225947 Activation of multiple signaling modules is critical in angiotensin IV-induced lung endothelial cell proliferation. 2002 Oct 2
240 12271141 Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. 2002 Oct 15 2
241 12433206 Constitutive activation of p70S6k in cancer cells. 2002 Oct 2
242 12553669 Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase. 2002 Dec 1
243 11272147 Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. 2001 Feb 2
244 11358856 The Ras radiation resistance pathway. 2001 May 15 1
245 11402043 Inhibition of p70(S6) kinase during transforming growth factor-beta 1/vitamin D(3)-induced monocyte differentiation of HL-60 cells allows tumor necrosis factor-alpha to stimulate plasminogen activator inhibitor-1 synthesis. 2001 Aug 24 1
246 11446769 HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing. 2001 Aug 1
247 11493700 p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. 2001 Aug 14 1
248 11709727 ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the phosphatidylinositol 3-kinase signaling pathway in anchorage-independent growth. 2001 Nov 8 1
249 11713299 Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation. 2001 Dec 1
250 11739559 Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells. 2001 Dec 1