Pub. Date : 2005 Jun
PMID : 15882288
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The p70(S6) kinase pathway leading to cell cycle progression was found to be active, and low concentrations of rapamycin dramatically reduced p70(S6) kinase phosphorylation. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | CONCLUSION: Rapamycin inhibits the proliferative response of HRECs to mitogenic stimuli, and causes cell cycle arrest in the early G(1) phase, not only by a nonspecific process due to inhibition of the p70(S6k) pathway, but also by a direct effect on cyclin D3 mRNA stability. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |