| 1 |
34731371 | mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma. | 2022 Jan |
3 |
| 2 |
33801030 | Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics. | 2021 Mar 21 |
1 |
| 3 |
34911836 | Screening and analysis for autophagy-related lncRNA in fibroblast-like synoviocytes from patients with rheumatoid arthritis. | 2021 Oct 28 |
2 |
| 4 |
31806641 | Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. | 2020 Feb 15 |
1 |
| 5 |
32512069 | Cu(II) disrupts autophagy-mediated lysosomal degradation of oligomeric Aβ in microglia via mTOR-TFEB pathway. | 2020 Aug 15 |
1 |
| 6 |
32861759 | Perfluorooctane sulfonate induced toxicity in embryonic stem cell-derived cardiomyocytes via inhibiting autophagy-lysosome pathway. | 2020 Dec |
1 |
| 7 |
30075169 | Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus. | 2019 Jan 10 |
1 |
| 8 |
30993706 | Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2-mTOR pathway. | 2019 Nov |
2 |
| 9 |
31771139 | Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer. | 2019 Nov 23 |
1 |
| 10 |
29080085 | Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model. | 2018 Apr |
1 |
| 11 |
29154199 | Ultraviolet B radiation down-regulates ULK1 and ATG7 expression and impairs the autophagy response in human keratinocytes. | 2018 Jan |
1 |
| 12 |
29344639 | Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study. | 2018 Apr |
1 |
| 13 |
29692710 | PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT. | 2018 |
1 |
| 14 |
29755672 | Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma. | 2018 Apr 17 |
4 |
| 15 |
30346178 | In Silico Discovery of a Small Molecule Suppressing Lung Carcinoma A549 Cells Proliferation and Inducing Autophagy via mTOR Pathway Inhibition. | 2018 Nov 5 |
2 |
| 16 |
28106723 | Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers. | 2017 Jan 17 |
2 |
| 17 |
28400912 | Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes. | 2017 |
1 |
| 18 |
28442344 | miR-221 regulates CD44 in hepatocellular carcinoma through the PI3K-AKT-mTOR pathway. | 2017 Jun 3 |
2 |
| 19 |
28612529 | [The Mechanism of Combination using mTORC1/2 Inhibitor and Imatinib to Suppress Cell Proliferation of Ph +ALL Cell Line]. | 2017 Mar |
1 |
| 20 |
26719046 | ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. | 2016 Mar |
1 |
| 21 |
26776341 | Effective targeting of colorectal cancer cells using TORC1/2 kinase inhibitors in vitro and in vivo. | 2016 Feb |
1 |
| 22 |
26891668 | Diallyl disulfide induces apoptosis and autophagy via mTOR pathway in myeloid leukemic cell line. | 2016 Aug |
1 |
| 23 |
26894601 | Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling. | 2016 Aug |
1 |
| 24 |
26940200 | Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling. | 2016 Mar 4 |
1 |
| 25 |
26956871 | Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy. | 2016 Jun |
2 |
| 26 |
26984042 | Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation. | 2016 May |
1 |
| 27 |
27566137 | mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts. | 2016 Dec |
1 |
| 28 |
25151963 | Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. | 2015 Jun |
1 |
| 29 |
25535978 | The antileukemia roles of PP242 alone or in combination with daunorubicin in acute leukemia. | 2015 Apr |
2 |
| 30 |
26041412 | The mammalian target of rapamycin signaling pathway regulates myocyte enhancer factor-2C phosphorylation levels through integrin-linked kinase in goat skeletal muscle satellite cells. | 2015 Nov |
1 |
| 31 |
26416965 | mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. | 2015 Sep 28 |
1 |
| 32 |
26586952 | Combination of cetuximab and PP242 synergistically suppress the progression of wild-type KRAS colorectal carcinoma. | 2015 |
2 |
| 33 |
26636543 | mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells. | 2015 Dec 29 |
1 |
| 34 |
26885449 | Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis. | 2015 |
1 |
| 35 |
23542178 | Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. | 2014 Mar 20 |
2 |
| 36 |
23907312 | Significance of mTOR signaling and its inhibitor against cancer stem-like cells in colorectal cancer. | 2014 Jan |
2 |
| 37 |
25035961 | PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. | 2014 Nov |
3 |
| 38 |
25392452 | A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. | 2014 Nov |
1 |
| 39 |
25482947 | mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. | 2014 |
1 |
| 40 |
23319802 | mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosis. | 2013 Mar 15 |
1 |
| 41 |
23362262 | Transforming growth factor β integrates Smad 3 to mechanistic target of rapamycin complexes to arrest deptor abundance for glomerular mesangial cell hypertrophy. | 2013 Mar 15 |
1 |
| 42 |
23437362 | Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. | 2013 |
1 |
| 43 |
23482748 | Comparative effects of PP242 and rapamycin on mTOR signalling and NOTCH signalling in leukemia cells. | 2013 Mar |
1 |
| 44 |
23547259 | Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. | 2013 Jun |
1 |
| 45 |
23722550 | Radioresistant cancer cells can be conditioned to enter senescence by mTOR inhibition. | 2013 Jul 15 |
1 |
| 46 |
23730416 | Competitive but Not Allosteric mTOR Kinase Inhibition Enhances Tumor Cell Radiosensitivity. | 2013 Jun |
1 |
| 47 |
23838676 | A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin. | 2013 Oct |
3 |
| 48 |
23991179 | Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma. | 2013 |
3 |
| 49 |
24008673 | Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to aurora inhibitors by suppression of glycolytic metabolism. | 2013 Nov |
2 |
| 50 |
22223645 | Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. | 2012 Mar 23 |
1 |