Title : Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma.

Pub. Date : 2013

PMID : 23991179






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The second generation of mTOR inhibitors such as PP242 targets mTOR kinase; thus, they are capable of inhibiting both mTORC1 and mTORC2. PP242 mechanistic target of rapamycin kinase Homo sapiens
2 The second generation of mTOR inhibitors such as PP242 targets mTOR kinase; thus, they are capable of inhibiting both mTORC1 and mTORC2. PP242 mechanistic target of rapamycin kinase Homo sapiens
3 To examine the therapeutic potential of the mTOR kinase inhibitors, we treated a panel of colorectal carcinoma cell lines with PP242. PP242 mechanistic target of rapamycin kinase Homo sapiens