Title : Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.

Pub. Date : 2012 Mar 23

PMID : 22223645






1 Functional Relationships(s)
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1 An intensive recent effort to develop ATP-competitive mTOR inhibitors has resulted in several potent and selective molecules such as Torin1, PP242, KU63794, and WYE354. PP242 mechanistic target of rapamycin kinase Homo sapiens