Cisplatin

mechanistic target of rapamycin kinase ; Homo sapiens







176 Article(s)
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151 22673193 Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPK-activated mTOR inhibition. 2012 Jun 7 3
152 22901187 Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict platinum-based chemotherapy response of advanced non-small cell lung cancers in a Chinese population. 2012 1
153 22985566 [CA916798 gene participates in cisplatin resistance of human lung adenocarcinoma A549 cells through PI3K/AKT/mTOR pathway]. 2012 Sep 3
154 23056046 Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFκB and Akt/mTOR Signaling Pathways. 2012 1
155 23056575 Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells. 2012 1
156 20686837 Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73. 2011 Jul 1
157 21050361 The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers. 2011 Jul 1
158 21358348 Temsirolimus inhibits malignant pleural mesothelioma growth in vitro and in vivo: synergism with chemotherapy. 2011 May 1
159 21764510 Inhibitors of mTOR overcome drug resistance from topoisomerase II inhibitors in solid tumors. 2011 Dec 1 1
160 19471857 The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines. 2010 Aug 1
161 19853261 Combined treatment with cisplatin and sirolimus to enhance cell death in human mesothelioma. 2010 May 1
162 20214883 Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells. 2010 Apr 9 8
163 20847160 18F-FLT PET as a surrogate marker of drug efficacy during mTOR inhibition by everolimus in a preclinical cisplatin-resistant ovarian tumor model. 2010 Oct 4
164 19058911 System L amino acid transporter inhibitor enhances anti-tumor activity of cisplatin in a head and neck squamous cell carcinoma cell line. 2009 Apr 8 2
165 19240722 The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. 2009 Mar 24 1
166 19484784 Synergistic effect of rapamycin and cisplatin in endometrial cancer cells. 2009 Sep 1 2
167 19540648 Aberration of the PI3K/AKT/mTOR signaling in epithelial ovarian cancer and its implication in cisplatin-based chemotherapy. 2009 Sep 4
168 19690197 mTOR is a promising therapeutic target both in cisplatin-sensitive and cisplatin-resistant clear cell carcinoma of the ovary. 2009 Sep 1 5
169 20066897 Combined effect of rapamycin and cisplatin on survival of Hep-2 cells in vitro. 2009 1
170 20196784 AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells. 2009 Sep 5
171 18058806 Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy. 2008 Jun 2
172 18585380 Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins. 2008 Sep 4 4
173 17616691 AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. 2007 Jul 1 5
174 17634556 RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model. 2007 Jul 15 1
175 16786123 Predictive and prognostic role of activated mammalian target of rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy. 2006 Jul 1
176 16033649 Overcoming cisplatin resistance by mTOR inhibitor in lung cancer. 2005 Jul 20 1