Title : Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73.

Pub. Date : 2011 Jul

PMID : 20686837






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1 Using a validated kinase inhibitor library, we showed that inhibition of the mTOR, TGFbetaRI, NFkappaB, PI3K/AKT, and MAPK pathways sensitized basal-like MDA-MB-468 cells to cisplatin treatment. Cisplatin mechanistic target of rapamycin kinase Homo sapiens