Title : Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy.

Pub. Date : 2008 Jun

PMID : 18058806






2 Functional Relationships(s)
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1 In the in vitro study, cisplatin at CPI(50) targets both the apoptosis and survival pathway by activating the caspase-cascade; inhibiting Akt, mTOR, p70S6K, and 4EBP1. Cisplatin mechanistic target of rapamycin kinase Homo sapiens
2 Inhibition of the mTOR pathway contributes to cisplatin-induced apoptosis in cervical cancer cell lines. Cisplatin mechanistic target of rapamycin kinase Homo sapiens