Cisplatin

mechanistic target of rapamycin kinase ; Homo sapiens







176 Article(s)
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1 34643088 GALNT14 regulates ferroptosis and apoptosis of ovarian cancer through the EGFR/mTOR pathway. 2022 Jan 1
2 35001804 Protein tyrosine phosphatase receptor type Z1 inhibits the cisplatin resistance of ovarian cancer by regulating PI3K/AKT/mTOR signal pathway. 2022 Jan 1
3 35057550 Olive Mill Wastewater Inhibits Growth and Proliferation of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro by Down-Regulating the Akt/mTOR-Signaling Pathway. 2022 Jan 15 1
4 35238281 BEZ235 reduction of cisplatin resistance on wild-type EGFR non-small cell lung cancer cells. 2022 Mar 3 3
5 35263216 Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis. 2022 Mar 2
6 33073679 mTOR Inhibition Ablates Cisplatin-Resistant Salivary Gland Cancer Stem Cells. 2021 Apr 5
7 33179318 Pseudogene KRT17P3 drives cisplatin resistance of human NSCLC cells by modulating miR-497-5p/mTOR. 2021 Jan 2
8 33568627 BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism. 2021 Feb 10 5
9 33575476 Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways. 2021 Mar 26 2
10 33717260 The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells. 2021 Apr 1
11 33846781 Metformin impairs cisplatin resistance effects in A549 lung cancer cells through mTOR signaling and other metabolic pathways. 2021 Jun 1
12 33908630 Cyanidin-3-O-glucoside and cisplatin inhibit proliferation and downregulate the PI3K/AKT/mTOR pathway in cervical cancer cells. 2021 Jun 1
13 34046349 Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway. 2021 2
14 34077013 Apatinib strengthens the anti-tumor effect of cisplatin in thyroid carcinoma through downregulating VEGFR2. 2021 Mar-Apr 4
15 34077027 Tormentic acid induces anticancer effects in cisplatin-resistant human cervical cancer cells mediated via cell cycle arrest, ROS production, and targeting mTOR/PI3K/AKT signalling pathway. 2021 Mar-Apr 2
16 34261004 Cisplatin's potential for type 2 diabetes repositioning by inhibiting CDKN1A, FAS, and SESN1. 2021 Aug 1
17 34277781 A novel peptide promotes human trophoblast proliferation and migration through PI3K/Akt/mTOR signaling pathway. 2021 Jun 2
18 34298686 Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux. 2021 Jul 11 1
19 34329824 Improved tumor-suppressive effect of OZ-001 combined with cisplatin mediated by mTOR/p70S6K and STAT3 inactivation in A549 human lung cancer cells. 2021 Oct 4
20 34427099 HDAC3-mediated lncRNA-LOC101928316 contributes to cisplatin resistance in gastric cancer via activating the PI3K-Akt-mTOR pathway. 2021 Sep 2
21 34543857 STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma. 2021 Sep 17 5
22 34876569 TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway. 2021 Dec 7 5
23 34915755 A nano based approach to alleviate cisplatin induced nephrotoxicity. 2021 Jan-Dec 1
24 31267531 microRNA-10b confers cisplatin resistance by activating AKT/mTOR/P70S6K signaling via targeting PPARγ in esophageal cancer. 2020 Feb 2
25 31558183 Overexpression of the Long Noncoding RNA FOXD2-AS1 Promotes Cisplatin Resistance in Esophageal Squamous Cell Carcinoma Through the miR-195/Akt/mTOR Axis. 2020 Feb 7 3
26 31843707 Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy. 2020 Mar 1
27 31913198 miR-21 modulates cisplatin resistance of gastric cancer cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway. 2020 Apr 3
28 31917287 TIPE2 suppressed cisplatin resistance by inducing autophagy via mTOR signalling pathway. 2020 Apr 2
29 32097729 ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells. 2020 May 2
30 32104214 Ghrelin inhibits cisplatin-induced MDA-MB-231 breast cancer cell apoptosis via PI3K/Akt/mTOR signaling. 2020 Mar 3
31 32131519 Unique Triterpenoid of Jujube Root Protects Cisplatin-induced Damage in Kidney Epithelial LLC-PK1 Cells via Autophagy Regulation. 2020 Mar 2 2
32 32267053 Salicylate sensitizes oral squamous cell carcinoma to chemotherapy through targeting mTOR pathway. 2020 Apr 8 1
33 32277616 Tormentic acid induces anticancer effects in cisplatin-resistant human cervical cancer cells mediated via cell cycle arrest, ROS production, and targeting mTOR/PI3K/AKT signalling pathway. 2020 Jan-Feb 2
34 32308804 Plumbagin Enhances the Anticancer Efficacy of Cisplatin by Increasing Intracellular ROS in Human Tongue Squamous Cell Carcinoma. 2020 1
35 32323781 MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway. 2020 Apr 9
36 32368441 The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair. 2020 Aug 2
37 32458975 SIK2 Promotes Cisplatin Resistance Induced by Aerobic Glycolysis in Breast Cancer Cells through PI3K/AKT/mTOR Signaling Pathway. 2020 May 27 3
38 32593915 Testicular cancer: Determinants of cisplatin sensitivity and novel therapeutic opportunities. 2020 Aug 1
39 32599072 Role of mTOR As an Essential Kinase in SCLC. 2020 Sep 1
40 32608202 Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells. 2020 Jul 3
41 32744675 MiR-100 up-regulation enhanced cell autophagy and apoptosis induced by cisplatin in osteosarcoma by targeting mTOR. 2020 Jul 1
42 32800561 Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway. 2020 Oct 20 1
43 32819590 GDC-0980 (apitolisib) treatment with gemcitabine and/or cisplatin synergistically reduces cholangiocarcinoma cell growth by suppressing the PI3K/Akt/mTOR pathway. 2020 Sep 3 1
44 33112540 Effect of Combined Sorafenib/Cisplatinum Treatment on the Autophagy and Proliferation of Hepatocellular Carcinoma hepG2 Cells in Vitro. 2020 Oct 1 2
45 33115978 Long Noncoding RNA HOXA11-AS Modulates the Resistance of Nasopharyngeal Carcinoma Cells to Cisplatin via miR-454-3p/c-Met. 2020 Oct 31 1
46 33123242 Synergistic antitumor effect of dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with cisplatin on drug-resistant non-small cell lung cancer cell. 2020 Dec 1
47 33275201 Regulation of mTOR by miR-107 to facilitate glioma cell apoptosis and to enhance cisplatin sensitivity. 2020 Nov 1
48 33362566 Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer. 2020 2
49 33391038 AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury. 2020 3
50 30144378 ADP sensitizes ZL55 cells to the activity of cisplatin. 2019 Apr 3