Pub. Date : 2021 Feb 10
PMID : 33568627
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | The cisplatin-induced up-regulation of BCAT1 decreased the cisplatin sensitivity by regulating autophagy through the mTOR signaling pathway. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | The cisplatin-induced up-regulation of BCAT1 decreased the cisplatin sensitivity by regulating autophagy through the mTOR signaling pathway. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | In addition, branched-chain amino acids or leucine treatment inhibited cisplatin- or BCAT1-mediated autophagy and increased cisplatin sensitivity by activating mTOR signaling in cancer cells. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | These findings demonstrate a new mechanism, revealing that BCAT1 decreases cisplatin sensitivity in cancer cells by inducing mTOR-mediated autophagy via branched-chain amino acid leucine metabolism, providing an attractive pharmacological target to improve the effectiveness of chemotherapy. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |