Pub. Date : 2021 Apr
PMID : 33073679
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | mTOR Inhibition Ablates Cisplatin-Resistant Salivary Gland Cancer Stem Cells. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | The purpose of this study was to investigate the effect of therapeutic inhibition of mTOR (mechanistic target of rapamycin) on resistance of CSCs to cisplatin, a prototypic platinum-based chemotherapeutic agent. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | The purpose of this study was to investigate the effect of therapeutic inhibition of mTOR (mechanistic target of rapamycin) on resistance of CSCs to cisplatin, a prototypic platinum-based chemotherapeutic agent. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | We observed that cisplatin induced mTOR and S6K1 phosphorylation, increased the number and size of MEC salispheres, and induced Bmi-1 expression and the fraction of CSCs in MEC models in vitro. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | In contrast, mTOR inhibition (e.g., temsirolimus) blocked cisplatin-induced Bmi-1 expression and salisphere formation in vitro. | Cisplatin | mechanistic target of rapamycin kinase | Homo sapiens |