Title : Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.

Pub. Date : 2009 Aug 15

PMID : 19679549






1 Functional Relationships(s)
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1 Metformin, the most widely used drug in the treatment of type 2 diabetes, activates AMP kinase (AMPK), which negatively regulates mTOR. Metformin mechanistic target of rapamycin kinase Homo sapiens