Pub. Date : 2007 Nov 15
PMID : 18006825
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | The decrease in translation caused by metformin was associated with mammalian target of rapamycin (mTOR) inhibition, and a decrease in the phosphorylation of S6 kinase, ribosomal protein S6, and eIF4E-binding protein 1. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | The decrease in translation caused by metformin was associated with mammalian target of rapamycin (mTOR) inhibition, and a decrease in the phosphorylation of S6 kinase, ribosomal protein S6, and eIF4E-binding protein 1. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | These results show that metformin-mediated AMPK activation leads to inhibition of mTOR and a reduction in translation initiation, thus providing a possible mechanism of action of metformin in the inhibition of cancer cell growth. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | These results show that metformin-mediated AMPK activation leads to inhibition of mTOR and a reduction in translation initiation, thus providing a possible mechanism of action of metformin in the inhibition of cancer cell growth. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |