Tetradecanoylphorbol Acetate

mitogen-activated protein kinase 8 ; Homo sapiens







117 Article(s)
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51 19010898 The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. 2008 Nov 15 5
52 17114644 Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. 2007 May 1
53 17404068 KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol ester-stimulated human breast epithelial cells. 2007 Jan 4
54 17600309 PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells. 2007 Nov 2
55 17880928 Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells. 2007 Dec 3 1
56 17982670 12-O-tetradecanoyl phorbol 13-acetate induces the expression of B7-DC, -H1, -H2, and -H3 in K562 cells. 2007 Dec 4
57 16267831 Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1. 2006 Jan 2
58 16434970 Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. 2006 May 18 1
59 16480952 Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells. 2006 Mar 31 3
60 16740769 Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice. 2006 Jun 1 2
61 16773182 MUC5AC mucin gene regulation in pancreatic cancer cells. 2006 Jul 1
62 17030510 Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. 2006 Dec 1 1
63 15707584 AP-1 regulates alpha2beta1 integrin expression by ERK-dependent signals during megakaryocytic differentiation of K562 cells. 2005 Mar 10 1
64 16102725 Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. 2005 Oct 7 1
65 14610070 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. 2004 Jan 30 1
66 14661062 Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. 2004 Mar 11 2
67 14709334 Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung cancer cells. 2004 Apr 2
68 14978257 Phorbol 12-myristate 13-acetate protects Jurkat cells from methylglyoxal-induced apoptosis by preventing c-Jun N-terminal kinase-mediated leakage of cytochrome c in an extracellular signal-regulated kinase-dependent manner. 2004 Mar 2
69 15041541 [Effects of mitogen-activated protein kinase on phorbol 12-myristate 13-acetate-induced matrix metalloproteinase-9 gene expression in cytotrophoblastic cells]. 2004 Mar 2
70 15138488 JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). 2004 May 17 7
71 15161022 EGCG blocks tumor promoter-induced MMP-9 expression via suppression of MAPK and AP-1 activation in human gastric AGS cells. 2004 Mar-Apr 2
72 15252145 Activation of protein kinase C betaII/epsilon-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin. 2004 Jul 3
73 15263067 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. 2004 Dec 2
74 12592382 ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. 2003 Feb 20 2
75 12593797 The JNK cascade as a biochemical switch in mammalian cells: ultrasensitive and all-or-none responses. 2003 Feb 18 2
76 12758252 Detection of JNK and p38 activation by flow cytometry analysis. 2003 Jun 15 1
77 12824193 Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. 2003 Sep 5 2
78 14612503 Interruption of nuclear factor kappaB signaling by the androgen receptor facilitates 12-O-tetradecanoylphorbolacetate-induced apoptosis in androgen-sensitive prostate cancer LNCaP cells. 2003 Nov 1 4
79 14672351 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation. 2003 Dec 1
80 11792626 JNK1 and AP-1 regulate PMA-inducible squamous differentiation marker expression in Clara-like H441 cells. 2002 Feb 1
81 11850819 C-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. 2002 Feb 7 5
82 11956220 Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1. 2002 Jun 21 1
83 12091247 BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells. 2002 Jul 2
84 12186945 PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells. 2002 Sep 15 1
85 11312276 How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. 2001 May 1 3
86 11353829 Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory crosstalk among MAPK family members. 2001 May 22 1
87 11356718 Insulin-induced c-Jun N-terminal kinase activation is negatively regulated by protein kinase C delta. 2001 Jun 2
88 10807930 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. 2000 Jul 28 14
89 11086177 The mechanism of geranylgeraniol-induced apoptosis involves activation, by a caspase-3-like protease, of a c-jun N-terminal kinase signaling cascade and differs from mechanisms of apoptosis induced by conventional chemotherapeutic drugs. 2000 Nov 4
90 9925763 Regulation of proliferation and apoptosis by epidermal growth factor and protein kinase C in human ovarian surface epithelial cells. 1999 Feb 1 1
91 10344756 Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells. 1999 May 15 5
92 10357879 Modulation of nitric oxide-induced apoptotic death of HL-60 cells by protein kinase C and protein kinase A through mitogen-activated protein kinases and CPP32-like protease pathways. 1999 May 25 2
93 10359012 Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059. 1999 May 2
94 10514454 Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines. 1999 Oct 15 3
95 10518804 Ca2+-induced p38/SAPK signalling inhibited by the immunosuppressant cyclosporin A in human peripheral blood mononuclear cells. 1999 Nov 1
96 10523856 Phorbol ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways. 1999 Oct 14 2
97 9467967 Arachidonic acid activates Jun N-terminal kinase in vascular smooth muscle cells. 1998 Jan 22 4
98 9478937 Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. 1998 Feb 27 2
99 9514879 Ionizing radiation activates c-Jun NH2-terminal kinase (JNK/SAPK) via a PKC-dependent pathway in human thyroid cells. 1998 Mar 6 2
100 9535820 Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis. 1998 Apr 7 3