Pub. Date : 2000 Jul 28
PMID : 10807930
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal kinase (JNK) phosphatase renders immortalized or transformed epithelial cells refractory to TPA-inducible JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | JNK can be activated by the tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal human oral keratinocytes but not in human keratinocytes that have been immortalized (HOK-16B and HaCaT) or transformed (HOK-16B-Bap-T) nor in a cervical carcinoma cell line (HeLa). | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 9 | JNK can be activated by the tumor promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA) in normal human oral keratinocytes but not in human keratinocytes that have been immortalized (HOK-16B and HaCaT) or transformed (HOK-16B-Bap-T) nor in a cervical carcinoma cell line (HeLa). | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 10 | The refractory JNK activation response to TPA is not due a defect in the JNK pathway, because JNK can be activated by other stimuli, e.g. UV irradiation and an alkylating agent N-methyl-N"-nitrosoguanidine in these immortalized or transformed cells. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 11 | More importantly, the refractory JNK and JNKK activation response to TPA can be restored by treatment of the cells with a combination of TPA and a protein-tyrosine phosphatase inhibitor, sodium orthovanadate. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 12 | More importantly, the refractory JNK and JNKK activation response to TPA can be restored by treatment of the cells with a combination of TPA and a protein-tyrosine phosphatase inhibitor, sodium orthovanadate. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 13 | Furthermore, pretreatment of cells with TPA partially inhibited UV- or N-methyl-N"-nitrosoguanidine-induced JNK activity. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |
| 14 | These results suggest that a TPA-inducible, orthovanadate-sensitive protein-tyrosine phosphatase may specifically down-regulate JNK signaling pathway in these immortalized/transformed epithelial cells. | Tetradecanoylphorbol Acetate | mitogen-activated protein kinase 8 | Homo sapiens |