Title : Extracellular signal-regulated kinase (ERK) activity is required for TPA-mediated inhibition of drug-induced apoptosis.

Pub. Date : 1998 Apr 7

PMID : 9535820






3 Functional Relationships(s)
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1 We report the use of 12-O-tetradecanoylphorbol-13-acetate (TPA) in the inhibition of apoptosis in HL-60 cells stimulated with the JNK/SAPK activator anisomycin. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
2 We report the use of 12-O-tetradecanoylphorbol-13-acetate (TPA) in the inhibition of apoptosis in HL-60 cells stimulated with the JNK/SAPK activator anisomycin. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens
3 Therefore, we conclude that TPA inhibits the induction of apoptosis in anisomycin-treated HL-60 cells through an ERK-dependent pathway and that this effect can be reversed by the attenuation of ERK activity accompanied with the stimulation of JNK/SAPK activity. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens