| 1 |
35364607 | Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells. | 2022 Jun 1 |
1 |
| 2 |
35429048 | Mutation in MCL1 predicted loop to helix structural transition stabilizes MCL1-Bax binding interaction favoring cancer cell survival. | 2022 Apr 16 |
1 |
| 3 |
34320168 | BCL2 and MCL1 inhibitors for hematologic malignancies. | 2021 Sep 30 |
1 |
| 4 |
34493661 | Lipids modulate the BH3-independent membrane targeting and activation of BAX and Bcl-xL. | 2021 Sep 14 |
2 |
| 5 |
34926454 | Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak. | 2021 |
1 |
| 6 |
31332296 | BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics. | 2020 Mar |
1 |
| 7 |
32390192 | Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax. | 2020 Jun |
1 |
| 8 |
32426354 | Phosphorylation-Dependent Pin1 Isomerization of ATR: Its Role in Regulating ATR's Anti-apoptotic Function at Mitochondria, and the Implications in Cancer. | 2020 |
1 |
| 9 |
33175095 | Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis. | 2020 Dec 11 |
1 |
| 10 |
30185825 | BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL. | 2019 Jun |
1 |
| 11 |
30970242 | BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association. | 2019 Apr 9 |
1 |
| 12 |
31285422 | Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis. | 2019 Jul 8 |
1 |
| 13 |
31341643 | DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis. | 2019 |
1 |
| 14 |
29229994 | Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion. | 2018 Mar |
1 |
| 15 |
29706657 | Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors. | 2018 Jul |
2 |
| 16 |
29987135 | Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. | 2018 Sep |
1 |
| 17 |
30128635 | Synthesis and Biological Activity of Scyllatoxin-Based BH3 Domain Mimetics Containing Two Disulfide Linkages. | 2018 Oct |
1 |
| 18 |
30334018 | BH3-Dependent and Independent Activation of BAX and BAK in Mitochondrial Apoptosis. | 2018 Jun |
1 |
| 19 |
28053104 | Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis. | 2017 Mar 15 |
1 |
| 20 |
28252652 | BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. | 2017 Mar 2 |
3 |
| 21 |
28326661 | Role of single disulfide linkages in the folding and activity of scyllatoxin-based BH3 domain mimetics. | 2017 May |
1 |
| 22 |
29176554 | Membrane insertion of the BAX core, but not latch domain, drives apoptotic pore formation. | 2017 Nov 24 |
1 |
| 23 |
26578184 | Allostery in BAX protein activation. | 2016 Nov |
1 |
| 24 |
26702098 | BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes. | 2016 Jan 18 |
2 |
| 25 |
26862853 | Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines. | 2016 Mar 8 |
1 |
| 26 |
27172402 | BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux. | 2016 Jul 2 |
3 |
| 27 |
25548100 | Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells. | 2015 Apr |
1 |
| 28 |
25684204 | Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. | 2015 Mar 5 |
1 |
| 29 |
25715028 | BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. | 2015 |
1 |
| 30 |
25887155 | Strategies targeting apoptosis proteins to improve therapy of chronic lymphocytic leukemia. | 2015 Sep |
1 |
| 31 |
26158515 | Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction. | 2015 Jul 9 |
1 |
| 32 |
25096574 | B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins. | 2014 Sep 19 |
1 |
| 33 |
22866921 | Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. | 2013 May |
1 |
| 34 |
23154865 | Enhanced heterodimerization of Bax by Bcl-2 mutants improves irradiated cell survival. | 2013 Feb |
1 |
| 35 |
23243017 | Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism. | 2013 Feb 15 |
2 |
| 36 |
23374333 | Unlatched BAX pairs for death. | 2013 Jan 31 |
1 |
| 37 |
23374347 | Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis. | 2013 Jan 31 |
2 |
| 38 |
23392123 | Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation. | 2013 May |
2 |
| 39 |
23404709 | Direct activation of full-length proapoptotic BAK. | 2013 Mar 12 |
1 |
| 40 |
23437261 | BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components. | 2013 |
2 |
| 41 |
23557083 | Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. | 2013 Sep |
1 |
| 42 |
23788040 | Three-dimensional structure of Bax-mediated pores in membrane bilayers. | 2013 Jun 20 |
2 |
| 43 |
24158446 | Structural insights of tBid, the caspase-8-activated Bid, and its BH3 domain. | 2013 Dec 13 |
1 |
| 44 |
22015607 | Bax dimerizes via a symmetric BH3:groove interface during apoptosis. | 2012 Apr |
8 |
| 45 |
22155216 | Peptide screening to knockdown Bcl-2's anti-apoptotic activity: implications in cancer treatment. | 2012 Apr 1 |
2 |
| 46 |
22579788 | The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells. | 2012 Oct 28 |
1 |
| 47 |
22634637 | Direct and selective small-molecule activation of proapoptotic BAX. | 2012 Jul |
2 |
| 48 |
21148306 | The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. | 2011 Mar 18 |
2 |
| 49 |
21441714 | Bid and Bax are involved in granulosa cell apoptosis during follicular atresia in porcine ovaries. | 2011 Jun |
1 |
| 50 |
21628457 | Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. | 2011 Jul 15 |
1 |