Title : Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.

Pub. Date : 2011 Jul 15

PMID : 21628457






1 Functional Relationships(s)
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1 However, by combining two BH3 mimetics, one that inhibits BCL2 and one that induces NOXA, apoptosis is induced within 6 h in a BAX/BAK-dependent manner. BH 3 BCL2 associated X, apoptosis regulator Homo sapiens